Abstract
Apoptosis induced by fucoxanthin in HL-60 cells was associated with a loss of mitochondrial membrane potential at an early stage, but not with an increase in reactive oxygen species. Fucoxanthin treatment caused cleavages of procaspase-3 and poly (ADP-ribose) polymerase without any effect on the protein level of Bcl-2, Bcl-X(L), or Bax. Apoptosis induction by fucoxanthin may be mediated via mitochondrial membrane permeabilization and caspase-3 activation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticarcinogenic Agents / pharmacology*
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Apoptosis / drug effects*
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Caspase 3
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Caspases / metabolism
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Cell Line, Tumor
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Humans
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Intracellular Membranes / drug effects
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Leukemia, Promyelocytic, Acute
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Mitochondria / drug effects
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Poly(ADP-ribose) Polymerases / metabolism
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Reactive Oxygen Species
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Xanthophylls / pharmacology*
Substances
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Anticarcinogenic Agents
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Reactive Oxygen Species
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Xanthophylls
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fucoxanthin
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Poly(ADP-ribose) Polymerases
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CASP3 protein, human
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Caspase 3
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Caspases