The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer

E Bromwich; D C McMillan; G W A Lamb; P A Vasey; M Aitchison

doi:10.1038/sj.bjc.6602152

The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer

Br J Cancer. 2004 Oct 4;91(7):1236-8. doi: 10.1038/sj.bjc.6602152.

Authors

E Bromwich¹, D C McMillan, G W A Lamb, P A Vasey, M Aitchison

Affiliation

¹ University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK.

Abstract

The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates, only C-reactive protein was a significant independent predictor of survival (HR 2.03, 95% CI 1.09-3.80, P=0.026).

Publication types

Clinical Trial

MeSH terms

Aged
Antineoplastic Agents / therapeutic use*
C-Reactive Protein / analysis*
Carcinoma, Renal Cell / drug therapy*
Carcinoma, Renal Cell / immunology*
Carcinoma, Renal Cell / pathology
Female
Health Status
Humans
Inflammation
Interferon-alpha / therapeutic use*
Kidney Neoplasms / drug therapy*
Kidney Neoplasms / immunology*
Kidney Neoplasms / pathology
Male
Middle Aged
Predictive Value of Tests
Prognosis
Survival Analysis
Treatment Outcome

Substances

Antineoplastic Agents
Interferon-alpha
C-Reactive Protein