Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH3)CL2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine

Fazlul Huq; Hassan Daghriri; Jun Qing Yu; Philip Beale; Keith Fisher

doi:10.1016/j.ejmech.2004.04.005

Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH3)CL2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine

Eur J Med Chem. 2004 Aug;39(8):691-7. doi: 10.1016/j.ejmech.2004.04.005.

Authors

Fazlul Huq¹, Hassan Daghriri, Jun Qing Yu, Philip Beale, Keith Fisher

Affiliation

¹ School of Biomedical Sciences, Cumberland Campus, C42, The University of Sydney, East Street, PO Box 170, Lidcombe, NSW 1825, Australia. f.huq@fhs.usyd.edu.au

PMID: 15276302
DOI: 10.1016/j.ejmech.2004.04.005

Abstract

Four trans-planaramineplatinum(II) complexes code named YH9, YH10, YH11 and YH12, each of the form trans-PtL(NH(3))Cl(2) where L = 2-hydroxypyridine and 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine for YH9, YH10, YH11 and YH12, respectively. All of the compounds have significant anticancer activity against human cancer cell lines. YH12 is found to be significantly more active than cisplatin against cisplatin-resistant ovary cell line A2780(cisR).

MeSH terms

Cell Line, Tumor
Humans
Imidazoles / analysis
Imidazoles / chemical synthesis*
Magnetic Resonance Spectroscopy
Organoplatinum Compounds / analysis
Organoplatinum Compounds / chemical synthesis*
Pyridines / analysis
Pyridines / chemical synthesis*
Pyridones / analysis
Pyridones / chemical synthesis*
Spectrum Analysis, Raman
Thymine / analogs & derivatives*
Thymine / analysis
Thymine / chemical synthesis*

Substances

Imidazoles
Organoplatinum Compounds
Pt(MeNH(2))(2)(ChmT-N3)
Pyridines
Pyridones
3-hydroxypyridine
2-hydroxypyridine
imidazole
imidazo(1,2-a)pyridine
Thymine