Abstract
Four trans-planaramineplatinum(II) complexes code named YH9, YH10, YH11 and YH12, each of the form trans-PtL(NH(3))Cl(2) where L = 2-hydroxypyridine and 3-hydroxypyridine, imidazole, and imidazo(1,2-alpha)pyridine for YH9, YH10, YH11 and YH12, respectively. All of the compounds have significant anticancer activity against human cancer cell lines. YH12 is found to be significantly more active than cisplatin against cisplatin-resistant ovary cell line A2780(cisR).
MeSH terms
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Cell Line, Tumor
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Humans
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Imidazoles / analysis
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Imidazoles / chemical synthesis*
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Magnetic Resonance Spectroscopy
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Organoplatinum Compounds / analysis
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Organoplatinum Compounds / chemical synthesis*
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Pyridines / analysis
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Pyridines / chemical synthesis*
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Pyridones / analysis
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Pyridones / chemical synthesis*
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Spectrum Analysis, Raman
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Thymine / analogs & derivatives*
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Thymine / analysis
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Thymine / chemical synthesis*
Substances
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Imidazoles
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Organoplatinum Compounds
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Pt(MeNH(2))(2)(ChmT-N3)
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Pyridines
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Pyridones
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3-hydroxypyridine
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2-hydroxypyridine
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imidazole
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imidazo(1,2-a)pyridine
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Thymine