Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide

Surattana Amnuoypol; Khanit Suwanborirux; Sunibhond Pummangura; Akinori Kubo; Chieko Tanaka; Naoki Saito

doi:10.1021/np030534o

Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide

J Nat Prod. 2004 Jun;67(6):1023-8. doi: 10.1021/np030534o.

Authors

Surattana Amnuoypol¹, Khanit Suwanborirux, Sunibhond Pummangura, Akinori Kubo, Chieko Tanaka, Naoki Saito

Affiliation

¹ Bioactive Marine Natural Products Chemistry Research Unit (BMNCU), Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.

PMID: 15217287
DOI: 10.1021/np030534o

Abstract

Four minor renieramycin-type derivatives, including renieramycins O (1o) and Q-S (1q-s), were isolated from the sponge Xestospongia sp. pretreated with potassium cyanide. Their structures were elucidated by comparison of spectral data with those of recently reported renieramycins M (1m) and N (1n). The results of transformation and cytotoxicity measurements are also described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylation
Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Tetrahydroisoquinolines / chemistry*
Tetrahydroisoquinolines / isolation & purification
Tetrahydroisoquinolines / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Tetrahydroisoquinolines
renieramycin O