Abstract
A new lanostane-type triterpene acid, (20xi)-3-oxolanosta-7,9(11),24-trien-21-oic acid (1; dehydrotrametenonic acid), along with a known triterpene acid, dehydroeburiconic acid (2), were isolated from the epidermis of the sclerotia of Poria cocos. The structure of 1 was analyzed on the basis of spectroscopic methods. Compounds 1 and 2 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with the 50% inhibition values of 45.5 microM (1) and 40.8 microM (2), and 86.5 microM (1) and 30.0 microM (2), respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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DNA Polymerase I / antagonists & inhibitors*
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DNA Polymerase beta / antagonists & inhibitors*
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Weight
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Polyporales / chemistry*
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Rats
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Triterpenes / chemical synthesis*
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Enzyme Inhibitors
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Triterpenes
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dehydroeburiconic acid
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dehydrotrametenonic acid
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DNA Polymerase I
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DNA Polymerase beta