Abstract
The large number of active combination chemotherapy regimens for most cancers has led to the need for better information to guide the 'standard' treatment for each patient. In an attempt to individualise therapy, pharmacogenetics and pharmacogenomics (a polygenic approach to pharmacogenetic studies) encompass the search for answers to the hereditary basis for interindividual differences in drug response. This review will focus on the results of studies assessing the effects of polymorphisms in drug-metabolising enzymes and drug targets on the toxicity and response to commonly used chemotherapy drugs. In addition, the need for polygenic pharmacogenomic strategies to identify patients at risk for adverse drug reactions will be highlighted.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / pharmacology*
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Dihydrouracil Dehydrogenase (NADP) / genetics
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Dihydrouracil Dehydrogenase (NADP) / pharmacology
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Glucuronosyltransferase / genetics
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Glucuronosyltransferase / pharmacology
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Glutathione Transferase / genetics
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Glutathione Transferase / pharmacology
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Humans
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Methyltransferases / genetics
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Methyltransferases / pharmacology
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Neoplasms / drug therapy*
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Neoplasms / genetics*
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Pharmacogenetics / trends*
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Polymorphism, Genetic*
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Thymidylate Synthase / genetics
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Thymidylate Synthase / pharmacology
Substances
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Antineoplastic Agents
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Dihydrouracil Dehydrogenase (NADP)
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Methyltransferases
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Thymidylate Synthase
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thiopurine methyltransferase
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UGT1A1 enzyme
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Glucuronosyltransferase
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Glutathione Transferase