Abstract
Two novel series of 1,4-naphthoquinone derivatives have been synthesized namely; N-ethoxycarbonyl-2-ethoxycarbonyloxy-3- alkyl-1,4-naphthoquinon-1-substituted phenylhydrazones 3a-f and 2-chlorocetyloxy-3-alkyl-1,4-naphthoquinone-1-substituted phenylhydrazones 4a-d. The antimicrobial activity as well as anticancer activity of these compounds have been evaluated. The acute toxicity of the active compounds was determined.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / toxicity
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Artemia
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Bacteria / drug effects*
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Naphthoquinones / chemical synthesis*
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Naphthoquinones / pharmacology*
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Naphthoquinones / toxicity
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Spectrophotometry, Infrared
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Indicators and Reagents
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Naphthoquinones