Thymidylate synthetase - a target enzyme in cancer chemotherapy

Biochim Biophys Acta. 1977 Dec 23;473(2):73-92. doi: 10.1016/0304-419x(77)90001-4.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Binding, Competitive
  • Cysteine / metabolism
  • DNA, Neoplasm / biosynthesis
  • Deoxyuracil Nucleotides / metabolism
  • Deoxyuracil Nucleotides / pharmacology*
  • Female
  • Floxuridine / metabolism
  • Floxuridine / pharmacology
  • Humans
  • In Vitro Techniques
  • Iodoacetamide / analogs & derivatives
  • Kinetics
  • Male
  • Methyltransferases / antagonists & inhibitors*
  • Models, Chemical
  • Neoplasms / drug therapy
  • Neoplasms / enzymology*
  • Neoplasms / metabolism
  • Tetrahydrofolates / metabolism
  • Thionucleotides / metabolism
  • Thionucleotides / pharmacology
  • Thymidylate Synthase / antagonists & inhibitors*
  • Thymidylate Synthase / metabolism
  • Thymine Nucleotides / metabolism
  • Thymine Nucleotides / pharmacology

Substances

  • DNA, Neoplasm
  • Deoxyuracil Nucleotides
  • Tetrahydrofolates
  • Thionucleotides
  • Thymine Nucleotides
  • Floxuridine
  • Methyltransferases
  • Thymidylate Synthase
  • Cysteine
  • Iodoacetamide