Abstract
Human papillomaviruses are necessary for the development of cervical neoplasia. Progress in our understanding of the epithelial biology of this common pathogen has greatly influenced current concepts of cervical carcinogenesis. This understanding has provided a framework for understanding the biologic basis of many diagnostic criteria. Furthermore, classification schemes, diagnostic testing, and clinical management have been modified and clarified in light of this knowledge.
MeSH terms
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Biomarkers
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Cell Transformation, Viral / physiology
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DNA Probes, HPV
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DNA, Viral
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Female
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Genes, Viral / genetics
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Humans
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Models, Genetic
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Molecular Diagnostic Techniques
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Papillomaviridae / isolation & purification*
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Papillomaviridae / pathogenicity
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Papillomaviridae / physiology*
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Papillomavirus Infections / classification
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Papillomavirus Infections / diagnosis
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Papillomavirus Infections / pathology
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Papillomavirus Infections / therapy
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Sensitivity and Specificity
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Species Specificity
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Tumor Virus Infections / classification
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Tumor Virus Infections / diagnosis
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Tumor Virus Infections / pathology
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Tumor Virus Infections / therapy
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Uterine Cervical Neoplasms / diagnosis*
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Uterine Cervical Neoplasms / pathology
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Uterine Cervical Neoplasms / virology*
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Viral Structural Proteins / genetics
Substances
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Biomarkers
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DNA Probes, HPV
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DNA, Viral
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Viral Structural Proteins