Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

Laurence de Leval; Noëlle Hardy; Manuel Deprez; Jean Delwaide; Jacques Belaïche; Jacques Boniver

doi:10.1007/s00428-002-0707-9

Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

Virchows Arch. 2002 Nov;441(5):462-5. doi: 10.1007/s00428-002-0707-9. Epub 2002 Aug 29.

Authors

Laurence de Leval¹, Noëlle Hardy, Manuel Deprez, Jean Delwaide, Jacques Belaïche, Jacques Boniver

Affiliation

¹ Department of Pathology, CHU of Liège, Sart-Tilman, 4000 Liège, Belgium. L.deLeval@ulg.ac.be

PMID: 12447676
DOI: 10.1007/s00428-002-0707-9

Abstract

We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with Zollinger-Ellison syndrome. There was extensive metastatic dissemination of the neuroendocrine component to regional lymph nodes and to the liver. The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / chemistry
Adenocarcinoma / secondary*
Adenocarcinoma, Papillary / chemistry
Adenocarcinoma, Papillary / secondary*
Aged
Aged, 80 and over
Biomarkers, Tumor / analysis
Chromogranin A
Chromogranins / analysis
Fatal Outcome
Humans
Immunoenzyme Techniques
Liver Neoplasms / secondary
Lymph Nodes / pathology
Lymphatic Metastasis
Male
Neoplasms, Multiple Primary*
Phosphopyruvate Hydratase / analysis
Stomach Neoplasms / chemistry
Stomach Neoplasms / pathology*
Zollinger-Ellison Syndrome / metabolism
Zollinger-Ellison Syndrome / pathology*

Substances

Biomarkers, Tumor
Chromogranin A
Chromogranins
Phosphopyruvate Hydratase