Abstract
Aquaporin 1 is a water channel protein. There was little aquaporin 1 immunoreactivity in normal brain parenchyma. In astrocytomas, aquaporin 1 was expressed in microvessel endothelia and neoplastic astrocytes. In metastatic carcinomas, aquaporin 1 was present in microvessel endothelia and reactive astrocytes. Aquaporin 1 may participate in the formation of brain tumour oedema.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / metabolism*
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Adenocarcinoma / secondary
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Aquaporin 1
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Aquaporins / metabolism*
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Astrocytes / metabolism
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Astrocytes / pathology
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Astrocytoma / metabolism*
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Astrocytoma / pathology
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Blood Group Antigens
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Blood-Brain Barrier / physiology
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Brain / metabolism*
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Brain / pathology
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Brain Edema / pathology
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Brain Neoplasms / metabolism*
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Brain Neoplasms / pathology
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Brain Neoplasms / secondary
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Gene Expression Regulation, Neoplastic
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Glial Fibrillary Acidic Protein / analysis
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Humans
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Immunoenzyme Techniques
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Microcirculation / pathology
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Neoplasm Staging
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Neovascularization, Pathologic
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Prognosis
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Up-Regulation
Substances
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AQP1 protein, human
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Aquaporins
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Blood Group Antigens
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Glial Fibrillary Acidic Protein
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Aquaporin 1