The Authors report a case of intestinal bleeding due to lipoma of the epatic flexure. Lipomas are the commonest mesenchymal benign tumors that can be found in the colon and are second as frequence only to the adenomatous polyps. They are most frequent in the right colon and shown an opposite distribution in comparison with adenocarcinomas and adenomatous polyps. When tumor size is greater than 3 cm, lipomas become symptomatic. Radiological and endoscopic investigations provide orientative elements for diagnosis. In lipomas less than 2 cm in diameter an endoscopic treatment is feasible.