A genome-based strategy uncovers frequent BRAF mutations in melanoma

Pamela M Pollock; Paul S Meltzer

doi:10.1016/s1535-6108(02)00089-2

A genome-based strategy uncovers frequent BRAF mutations in melanoma

Cancer Cell. 2002 Jul;2(1):5-7. doi: 10.1016/s1535-6108(02)00089-2.

Authors

Pamela M Pollock¹, Paul S Meltzer

Affiliation

¹ Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

PMID: 12150818
DOI: 10.1016/s1535-6108(02)00089-2

Abstract

Using a genome-scanning approach to search for oncogenes, a recent report identifies somatic mutations in the signaling gene BRAF that are particularly prevalent in melanoma.

MeSH terms

Cell Transformation, Neoplastic
Humans
Melanoma / enzymology
Melanoma / genetics*
Melanoma / metabolism
Melanoma / pathology
Mitogen-Activated Protein Kinases / metabolism
Models, Biological
Mutation*
Point Mutation / genetics
Protein Structure, Tertiary
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-raf / chemistry
Proto-Oncogene Proteins c-raf / genetics*
Proto-Oncogene Proteins c-raf / metabolism
Signal Transduction
Tumor Cells, Cultured
ras Proteins / metabolism

Substances

BRAF protein, human
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-raf
Mitogen-Activated Protein Kinases
ras Proteins