The phosphatidylinositol 3-Kinase AKT pathway in human cancer

Nat Rev Cancer. 2002 Jul;2(7):489-501. doi: 10.1038/nrc839.

Authors

Igor Vivanco¹, Charles L Sawyers

Affiliation

¹ Department of Medicine and Molecular Biology Institute, UCLA School of Medicine, 11-935 Factor Building, 10833 LeConte Avenue, Los Angeles, California 90095, USA.

PMID: 12094235
DOI: 10.1038/nrc839

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Cell Division
Disease Models, Animal
Gene Deletion
Humans
Lipids
Mice
Models, Biological
Neoplasms / enzymology*
Phenotype
Phosphatidylinositol 3-Kinases / metabolism
Phosphatidylinositol 3-Kinases / physiology*
Phosphatidylinositol Phosphates / physiology
Protein Biosynthesis
Protein Serine-Threonine Kinases*
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-akt
Signal Transduction*

Substances

Lipids
Phosphatidylinositol Phosphates
Proto-Oncogene Proteins
phosphatidylinositol 3,4,5-triphosphate
AKT1 protein, human
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt