Abstract
Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl chloride (PC)-induced contact dermatitis in experimental animals. CM-ext showed inhibitory effects on these allergic models. Osthol isolated from CM-ext also had the inhibitory effects. These results suggested that Cnidii Monnieri Fructus might be useful as an agent for allergic diseases and that its anti-allergic effect was partially attributable to a coumarin derivative, osthol.
MeSH terms
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Animals
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Anti-Allergic Agents / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cnidium / chemistry*
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Coumarins / chemistry
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Coumarins / pharmacology*
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Dermatitis, Contact / pathology
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Dermatitis, Contact / prevention & control
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Dinitrofluorobenzene / antagonists & inhibitors
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Dinitrofluorobenzene / toxicity
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Diphenhydramine / pharmacology
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Fruit / chemistry*
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Mice, Inbred ICR
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Passive Cutaneous Anaphylaxis / drug effects
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Picryl Chloride / antagonists & inhibitors
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Picryl Chloride / toxicity
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Plant Extracts / pharmacology
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Prednisolone / pharmacology
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Pruritus / chemically induced
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Rats
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Rats, Wistar
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Skin / pathology
Substances
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Anti-Allergic Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Coumarins
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Plant Extracts
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Diphenhydramine
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Prednisolone
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Dinitrofluorobenzene
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osthol
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Picryl Chloride