Abstract
Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.
MeSH terms
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Amino Acid Sequence
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Carbohydrate Sequence
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Glycosylation
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Humans
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Molecular Sequence Data
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Mucin-5B
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Mucins / biosynthesis
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Mucins / chemistry*
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Oligosaccharides / chemistry
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Peptides / chemistry
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Protein Structure, Tertiary
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Saliva / metabolism*
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Salivary Proteins and Peptides / biosynthesis
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Salivary Proteins and Peptides / chemistry*
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Sequence Homology, Amino Acid
Substances
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MUC5B protein, human
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MUC7 protein, human
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Mucin-5B
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Mucins
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Oligosaccharides
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Peptides
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Salivary Proteins and Peptides