Developmental biology: vasculogenesis is a wreck without RECK

Curr Biol. 2002 Mar 19;12(6):R209-11. doi: 10.1016/s0960-9822(02)00752-2.

Abstract

The unique membrane-associated inhibitor of matrix metalloproteinases, RECK, is required for vascular maturation during embryogenesis. The phenotype of a loss of function mutation of RECK shows the importance of pericellular proteolysis in development.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blood Vessels / embryology
  • Blood Vessels / metabolism
  • Endothelium, Vascular / growth & development*
  • GPI-Linked Proteins
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Neoplastic
  • Glycoproteins / metabolism
  • Humans
  • Matrix Metalloproteinases / metabolism
  • Membrane Glycoproteins / genetics*
  • Membrane Glycoproteins / metabolism*
  • Molecular Sequence Data
  • Mutation
  • Sequence Homology, Amino Acid
  • Tissue Inhibitor of Metalloproteinase-2 / metabolism

Substances

  • GPI-Linked Proteins
  • Glycoproteins
  • Membrane Glycoproteins
  • RECK protein, human
  • tissue-factor-pathway inhibitor 2
  • Tissue Inhibitor of Metalloproteinase-2
  • Matrix Metalloproteinases