Abstract
Interleukin-10 (IL-10) is an immunomodulative cytokine produced by T cells, B cells, and monocytic cells. The significance of IL-10 and IL-10R expression in renal cell carcinoma (RCC) has not been well characterized. In this study, we assessed the correlation between IL-10 gene expression and its pathological significance in 44 RCC specimens. The patients with IL-10 gene expression showed a decreased incidence of metastasis compared to those without IL-10 gene expression. The expression of IL-10 was correlated with vascular endothelial growth factor (VEGF)-A gene expression. These findings suggest that IL-10 gene expression plays some roles in the metastasis of RCC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiopoietin-2
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Animals
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Carcinoma, Renal Cell / genetics*
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Carcinoma, Renal Cell / secondary
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Endothelial Growth Factors / genetics*
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Endothelial Growth Factors / metabolism
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Female
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Gene Expression Regulation, Neoplastic / physiology*
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Humans
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Immunoenzyme Techniques
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Interleukin-10 / genetics*
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Interleukin-10 / metabolism
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Kidney Neoplasms / genetics*
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Kidney Neoplasms / pathology
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Male
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Mice
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Mice, SCID
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Middle Aged
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Polymerase Chain Reaction
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Proteins / genetics
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Proteins / metabolism
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RNA, Messenger / metabolism
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Receptors, Interleukin / genetics
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Receptors, Interleukin / metabolism
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Receptors, Interleukin-10
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Reverse Transcriptase Polymerase Chain Reaction
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Thrombospondin 1 / genetics
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Thrombospondin 1 / metabolism
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Thrombospondins / genetics
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Thrombospondins / metabolism
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Vascular Endothelial Growth Factor A
Substances
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Angiopoietin-2
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Endothelial Growth Factors
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Proteins
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RNA, Messenger
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Receptors, Interleukin
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Receptors, Interleukin-10
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Thrombospondin 1
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Thrombospondins
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Vascular Endothelial Growth Factor A
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thrombospondin 2
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Interleukin-10