Expression of heparin-binding epidermal growth factor-like growth factor in breast carcinoma

Y Ito; T Takeda; S Higashiyama; S Noguchi; N Matsuura

doi:10.1023/a:1010667108371

Expression of heparin-binding epidermal growth factor-like growth factor in breast carcinoma

Breast Cancer Res Treat. 2001 May;67(1):81-5. doi: 10.1023/a:1010667108371.

Authors

Y Ito¹, T Takeda, S Higashiyama, S Noguchi, N Matsuura

Affiliation

¹ Department of Surgery, Osaka Seamen's Insurance Hospital, Japan.

PMID: 11518469
DOI: 10.1023/a:1010667108371

Abstract

The expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) was investigated for 76 cases of breast carcinoma. HB-EGF was expressed in 71.8% of the carcinoma cases but only slightly in normal mammary glands. Interestingly, its expression was inversely related to biological aggressiveness of the breast carcinoma. These results suggest that HB-EGF may play a crucial role in the early stage of this carcinoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Carcinoma / metabolism*
Carcinoma / pathology
Epidermal Growth Factor / metabolism*
Female
Heparin-binding EGF-like Growth Factor
Humans
Intercellular Signaling Peptides and Proteins
Middle Aged
Neoplasm Proteins / metabolism*
Prognosis

Substances

HBEGF protein, human
Heparin-binding EGF-like Growth Factor
Intercellular Signaling Peptides and Proteins
Neoplasm Proteins
Epidermal Growth Factor