Abstract
The methanol extract of the dried aerial parts of Prangos tschimganica gave three new coumarin derivatives and 30 known coumarin derivatives. Their structures were established on the basis of chemical and spectroscopic evidence. Absolute configuration of the isolated compounds were determined by using a modified Mosher's method. Some of the isolated compounds showed anti-HIV activity.
MeSH terms
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Acetylation
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / pharmacology
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Apiaceae / chemistry*
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Coumarins / chemistry*
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Coumarins / pharmacology
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Furocoumarins / chemistry*
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Furocoumarins / pharmacology
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HIV-1 / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Plants, Medicinal / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Uzbekistan
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Zidovudine / pharmacology
Substances
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Anti-HIV Agents
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Coumarins
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Furocoumarins
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Zidovudine