Abstract
Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzophenones / chemistry
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Benzophenones / isolation & purification*
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Benzophenones / pharmacology
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Cell Line
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DNA / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Magnoliopsida / chemistry*
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Spectrum Analysis
Substances
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Antineoplastic Agents, Phytogenic
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Benzophenones
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DNA