Abstract
ZO-1, ZO-2 and ZO-3 are tight junction (TJ)-associated proteins that belong to the MAGUK family. In addition to the presence of the characteristic MAGUK modules (PDZ, SH3 and GK), ZOs have a distinctive carboxyl terminal with splicing domains, acidic- and proline-rich regions. The modular organization of these proteins allows them to function as scaffolds, which associate to transmembrane TJ proteins, the cytoskeleton and signal transduction molecules. ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression.
Copyright 2000 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carrier Proteins / chemistry
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Carrier Proteins / physiology
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Connexin 43 / physiology
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Cytoskeleton / physiology
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Guanylate Kinases
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Humans
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Macromolecular Substances
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Membrane Proteins / chemistry
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Membrane Proteins / physiology
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Nucleoside-Phosphate Kinase / chemistry*
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Nucleoside-Phosphate Kinase / physiology*
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Occludin
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Phosphoproteins / chemistry
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Phosphoproteins / physiology
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Phosphorylation
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Protein Structure, Tertiary
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Tight Junctions / physiology*
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Zonula Occludens Proteins
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Zonula Occludens-1 Protein
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Zonula Occludens-2 Protein
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src Homology Domains
Substances
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Carrier Proteins
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Connexin 43
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Macromolecular Substances
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Membrane Proteins
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OCLN protein, human
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Occludin
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Phosphoproteins
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TJP1 protein, human
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TJP2 protein, human
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TJP3 protein, human
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Zonula Occludens Proteins
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Zonula Occludens-1 Protein
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Zonula Occludens-2 Protein
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Nucleoside-Phosphate Kinase
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Guanylate Kinases