Abstract
The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Recent studies have revealed that a number of proteins such as, the tumor suppressor APC and Axin are involved in the regulation of the Wnt signaling pathway. Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers.
MeSH terms
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Amino Acid Sequence
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Animals
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Axin Protein
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / physiology*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Embryonic and Fetal Development
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Genes, APC
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Humans
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Lymphoid Enhancer-Binding Factor 1
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Molecular Sequence Data
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Mutation
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Neoplasms / etiology
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Proteins / physiology
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Proto-Oncogene Proteins / physiology*
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Repressor Proteins*
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Signal Transduction
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Trans-Activators*
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Transcription Factors / chemistry
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Transcription Factors / genetics
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Transcription Factors / physiology
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Wnt Proteins
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Zebrafish Proteins*
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beta Catenin
Substances
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Axin Protein
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CTNNB1 protein, human
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Lymphoid Enhancer-Binding Factor 1
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Proteins
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Proto-Oncogene Proteins
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Repressor Proteins
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Trans-Activators
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Transcription Factors
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Wnt Proteins
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Zebrafish Proteins
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beta Catenin