Bioactivities of chalcones

Curr Med Chem. 1999 Dec;6(12):1125-49.

Abstract

This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as antimicrobial agents. The antiviral, antiprotozoal and insecticidal activities of a variety of chalcones are reviewed as well as the enzyme-inhibitory properties and miscellaneous activities of some of these molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Antiprotozoal Agents / pharmacology
  • Antiviral Agents / pharmacology
  • Chalcone / analogs & derivatives
  • Chalcone / pharmacology*
  • Chalcone / therapeutic use
  • Drug Screening Assays, Antitumor
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Mutagens / pharmacology

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antiprotozoal Agents
  • Antiviral Agents
  • Enzyme Inhibitors
  • Mutagens
  • Chalcone