Serrated adenoma and colorectal cancer

J Pathol. 1999 Apr;187(5):499-502. doi: 10.1002/(SICI)1096-9896(199904)187:5<499::AID-PATH309>3.0.CO;2-B.

Abstract

Hyperplastic polyps and serrated adenomas of the colorectum show mixed gastrointestinal differentiation, expressing both gastric (M1 or MUC5AC) and intestinal (MUC2) mucins. They also share the phenotype of mild DNA microsatellite instability (MSI-L). Recent findings of clonal genetic changes within hyperplastic polyps fit with a pathway of serrated neoplasia, perhaps culminating in the subset of colorectal cancer characterized by the mild mutator phenotype.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Adenoma / metabolism
  • Adenoma / pathology*
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology*
  • Humans
  • Hyperplasia / metabolism
  • Hyperplasia / pathology
  • Intestinal Polyps / genetics
  • Intestinal Polyps / metabolism
  • Intestinal Polyps / pathology*
  • Intestine, Large / metabolism
  • Intestine, Large / pathology*
  • Microsatellite Repeats / genetics
  • Mucins / metabolism
  • Neoplasm Proteins / metabolism
  • Precancerous Conditions / metabolism
  • Precancerous Conditions / pathology*

Substances

  • Mucins
  • Neoplasm Proteins