Abstract
Sandalwood oil, the essential oil of Santalum album L., was tested for in vitro antiviral activity against Herpes simplex viruses-1 and -2. It was found that the replication of these viruses was inhibited in the presence of the oil. This effect was dose-dependent and more pronounced against HSV-1. A slight diminution of the effect was observed at higher multiplicity of infections. The oil was not virucidal and showed no cytotoxicity at the concentrations tested.
MeSH terms
-
Animals
-
Antiviral Agents / pharmacology*
-
Chlorocebus aethiops
-
Dose-Response Relationship, Drug
-
Herpesvirus 1, Human / drug effects*
-
Herpesvirus 1, Human / growth & development
-
Herpesvirus 1, Human / physiology
-
Herpesvirus 2, Human / drug effects*
-
Herpesvirus 2, Human / growth & development
-
Herpesvirus 2, Human / physiology
-
Microbial Sensitivity Tests
-
Plant Oils / pharmacology*
-
Vero Cells
-
Viral Plaque Assay
-
Virus Replication / drug effects
Substances
-
Antiviral Agents
-
Plant Oils