In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones

M Kawase; H Harada; S Saito; J Cui; S Tani

doi:10.1016/s0960-894x(98)00726-4

In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones

Bioorg Med Chem Lett. 1999 Jan 18;9(2):193-4. doi: 10.1016/s0960-894x(98)00726-4.

Authors

M Kawase¹, H Harada, S Saito, J Cui, S Tani

Affiliation

¹ Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.

PMID: 10021926
DOI: 10.1016/s0960-894x(98)00726-4

Abstract

Heteroaromatic trifluoromethyl ketones (TFMK's) showed strong inhibitory activity against Helicobacter pylori. The MIC50 observed for 2-trifluoroacetonylbenzoxazole (1) is 20-fold more active than metronidazole and is only twice as high as that of clarithromycin. The inhibitory mode of TFMK's on Hp growth was not related to inhibition of urease.

MeSH terms

Benzoxazoles / pharmacology*
Helicobacter pylori / drug effects*
Inhibitory Concentration 50
Ketones / pharmacology*

Substances

2-trifluoroacetonylbenzoxazole
Benzoxazoles
Ketones