Original ContributionIntensity-Modulated Radiation Therapy for the Treatment of Anal Cancer
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Cited by (21)
Gastrointestinal
2020, Proton Therapy: Indications, Techniques and OutcomesRadiotherapy for anal canal cancers
2016, Cancer/RadiotherapieInitial Report of Pencil Beam Scanning Proton Therapy for Posthysterectomy Patients with Gynecologic Cancer
2016, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Strategies to limit the bone marrow dose using intensity modulated radiation therapy (IMRT) have been evaluated, with recent studies demonstrating that the volume of PBM receiving 10 and 20 Gy (V10, V20, respectively) is significantly associated with the development of acute hematologic toxicity in women receiving concurrent platinum-based chemotherapy (7, 8). One of the potential consequences of bone marrow sparing using IMRT is greater incidental doses to other organs at risk (OARs), because the beam angles and dose constraints chosen to avoid high doses to the bone marrow will result in consequently higher doses to other OARs (9). The physical characteristics of protons allow for irradiation of the target with a minimal exit and integral dose, which might result in lower collateral irradiation to normal structures (ie, bone marrow, bowel) compared with IMRT (10, 11).
Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer
2015, Radiotherapy and OncologyOrgan-sparing Intensity-modulated Radiotherapy for Anal Cancer using the ACTII Schedule: A Comparison of Conventional and Intensity-modulated Radiotherapy Plans
2013, Clinical OncologyCitation Excerpt :We consider IMRT1 to be the best compromise to meet our conditions to: (a) adhere to standard UK radiotherapy practice with respect to dose and target volume and (b) minimise the effect that a possible change in practice may have on clinical departments. Our IMRT technique is less complicated than those reported by other investigators as we only use seven beams spaced at variable angles compared with eight to10 equally spaced beams [6,17,18]. This may be due to the smaller target volumes and lower prescription dose.
Clinical target volumes in anal cancer: Calculating what dose was likely to have been delivered in the UK ACT II trial protocol
2012, Radiotherapy and OncologyCitation Excerpt :Results showed improved local control, overall survival and reduced acute and late toxicity, but patients receiving 3D conformal radiotherapy had treatment over 6 weeks continuously as opposed to 8–12 weeks (split course) in patients receiving conventional treatment, i.e. shortening the overall treatment time. With IMRT, radiation dose to OARs is reduced compared with conventional 2D and more sophisticated 3D treatment planning [23–25]. Pilot studies (single centre and multicentre) have been conducted which have shown IMRT to be well tolerated with mild to moderate acute symptoms, and few patients experiencing treatment breaks [26,27].
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