Document Type : Systematic Review and Meta-analysis
Authors
1
Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3
Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran.
4
Bam University of Medical Sciences, Department of Healthcare Management, Bam, Iran.
5
Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
6
Mother and New Born Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
7
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
Objective: Epidemiological studies have suggested that the promoter region polymorphisms of interleukin-10 (IL-10)
gene may be associated with an increased risk of lung cancer. However, those studies results are controversial. Thus, a
comprehensive meta-analysis was performed to evaluate the association of promoter region polymorphisms of IL-10
gene with susceptibility to lung cancer. Methods: a comprehensive search of PubMed, EMBASE, and CNKI databases
was performed to find all eligible studies up to September 15, 2018. The pooled odds ratios (ORs) with 95% confidence
intervals (CIs) were used to assess the strength of such association. Results: A total number of 19 case-control studies with
4084 cases and 6,131 controls were selected. The overall meta-analysis results showed that the -592A>C polymorphism
was significantly associated with lung cancer risk under four genetic models, i.e., allele (CT vs. TT: OR= 1.17, 95% CI
1.01-1.35, p=0.02), homozygote (CC vs. AA: OR= 1.64, 95% CI 1.29-2.02, p≤0.001), heterozygote (CA vs. AA: OR=
1.26, 95% CI 1.06-1.50, p≤0.001), and dominant (CC+CA vs. AA: OR= 1.31, 95% CI 1.11-1.54, p=0.001). However,
there was no significant association between -819T>C and -1082A>G polymorphisms of IL-10 and lung cancer risk.
Similarly, subgroup analyses by ethnicity detected significant association between IL-10 -592A>C and lung cancer
among Asians and Caucasians. Conclusions: Our meta-analysis suggests that the IL-10 -592A>C polymorphism might
be risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>G
polymorphisms are not significantly associated with increased risk of lung cancer.
Keywords
Main Subjects
)