Rous-Whipple Award Lecture
Liver Regeneration after Partial Hepatectomy: Critical Analysis of Mechanistic Dilemmas

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Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration. The complexity of the signaling pathways initiating and terminating this process have provided paradigms for regenerative medicine. Many aspects of the signaling mechanisms involved in hepatic regeneration are under active investigation. The purpose of this review is to focus on the areas still not well understood. The review also aims to provide insights into the ways by which current concepts of liver regeneration can provide understanding regarding malfunction of the regenerative process in liver diseases, such as acute liver failure.

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The Rous-Whipple Award is given by the American Society for Investigative Pathology to a senior pathologist with a distinguished career in experimental pathology research and continued productivity at the time of the award. George K. Michalopoulos, recipient of the 2009 ASIP Rous-Whipple Award, delivered a lecture entitled “Liver Regeneration,” on April 19, 2009 at the annual meeting of the American Society for Investigative Pathology in New Orleans, Louisiana.