Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

Title: Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

Volume: 2 Issue: 3

Author(s): Robert H. Shoemaker, Dominic A. Scudiero, Giovanni Melillo, Michael J. Currens, Anne P. Monks, Alfred A. Rabow, David G. Covell and Edward A. Sausville

Affiliation:

Keywords: anticancer drug discovery, molecular medicine, (cat) assays

Abstract: Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology,”rational“ drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.

Cite this article as:

Shoemaker H. Robert, Scudiero A. Dominic, Melillo Giovanni, Currens J. Michael, Monks P. Anne, Rabow A. Alfred, Covell G. David and Sausville A. Edward, Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery, Current Topics in Medicinal Chemistry 2002; 2 (3) . https://dx.doi.org/10.2174/1568026023394317