Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Phosphaturic Mesenchymal Tumor with Symptoms Related to Osteomalacia that Appeared One Year after Tumorectomy
Katsunobu Yoshioka, Rie Nagata, Mami Ueda, Toshimasa Yamaguchi, Yoshio Konishi, Masayuki Hosoi, Takeshi Inoue, Kazuhiro Yamanaka, Yoshiyasu Iwai, Toshihiko Sato
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Keywords: phosphaturic mesenchyal tumor, tumor-induced osteomalacia fibroblast growth factor 23, octreotide
JOURNAL OPEN ACCESS

2006 Volume 45 Issue 20 Pages 1157-1160

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Abstract

A 45-year-old man was admitted to our hospital because of bone pain and hypophosphatemia. He had undergone surgery 2 years previously for a "benign unclassified mesenchymal tumor" in the skull, but there were no clinical symptoms related to osteomalacia. His laboratory examination revealed low serum phosphate, high alkaline phosphatase, and normal calcium levels. The diagnosis of tumor-induced osteomalacia due to phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) was made by re-examining the pathologic specimens. Oral supplementation with phosphate and 1-25-dihydroxyvitamin D relieved his clinical symptoms and laboratory values returned to normal. However, subcutaneous administration of octreotide had no clinical effect. Clinicians and pathologists should be aware of the existence of PMTMCT especially nonphosphaturic or asymptomatic variants of this disorder.

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© 2006 by The Japanese Society of Internal Medicine
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