1999 Volume 35 Issue 2 Pages 47-54
To confirm the usefulness of Dai-kenchu-to for intestinal obstruction, investigation of the effects of Dai-kenchu-to on postoperative intestinal adhesion was conducted. Repeated administrations of Dai-kenchu-to (100 or 300 mg/kg) significantly inhibited the formation of intestinal obstruction. Motor disturbance and inflammation are thought to be involved in the etiology of intestinal adhesion. A single treatment of Dai-kenchu-to (300mg/kg) significantly reduce intestinal transit time in postoperative ileus and chemically-induced ileus. Dai-kenchu-to (10-4 g/ml) significantly inhibited COX-2 activity.
These results suggest that Dai-kenchu-to prevents postoperative intestinal adhesion by gastroprokinetic and anti-inflammatic effects. Dai-kenchu-to thus demonstrates positive effect on postoperative ileus.
