Chest
ORIGINAL RESEARCHINTERSTITIAL LUNG DISEASEAcute Exacerbation of Interstitial Pneumonia Other Than Idiopathic Pulmonary Fibrosis
Section snippets
Diagnostic Criteria
For the diagnosis of I-NSIP and the individual pattern of interstitial pneumonia, we used the American Thoracic Society/European Respiratory Society consensus classification, and individual CVDs were diagnosed according to the criteria of each society.19202122232425 For the diagnosis of AE, we used the Akira criteria7: (1) subjective worsening of dyspnea within the last 1 month; (2) new ground-glass opacities or consolidation on chest radiograph or high-resolution CT (HRCT); (3) hypoxemia with
Frequency of AE
Among 74 patients with surgical lung biopsy-confirmed fibrotic I-NSIP, the estimated 1-year frequency of AE was 4.2%. The estimated 1-year frequency in surgical lung biopsy-confirmed CVD-IP (n = 93) was 3.3% (Fig 1); however, it was 5.6% among the patients with CVD-UIP (n = 36) and 11.1% in RA-UIP (n = 18).
Demographic and Clinical Features
Demographic and clinical characteristics are shown in Table 1. Median age at the time of AE was 58 years (range, 47 to 75); six patients (60%) were female. Two patients (I-NSIP, n =
Discussion
Our experience showed that AE occurred in the patients with I-NSIP and CVD-IP. The estimated 1-year frequency of AE in our series was 4.2% in surgical lung biopsy-confirmed I-NSIP, 3.3% in CVD-IP, 5.6% in surgical biopsy-proven CVD-UIP, and 11.1% in RA-UIP. The clinical, radiologic, and pathologic features of our patients were similar to that of IPF. The exact frequency of AE in IPF is not known, and the reported numbers vary widely because of the difference in study design, and also due to the
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This work was performed in the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center.
All of the authors contributed substantially to this work and are all responsible for the content of the article. The authors have no conflicts of interest in association with this article to disclose.