Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
Takeshi SakataNaohiko AnzaiToru KimuraDaisaku MiuraToshiyuki FukutomiMichio TakedaHiroyuki SakuraiHitoshi Endou
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2010 Volume 113 Issue 3 Pages 263-266

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Abstract

We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [3H]histamine and [3H]MPP+, although their protein expressions were detected in the plasma membrane of transfected cells. This study suggests that the OCT3 variants will contribute to inter-individual variations leading to the differences in cationic drug disposition as well as certain disease processes such as hypertension, allergic diseases, and neuropsychiatric diseases by the clearance of endogenous organic cations such as biogenic amines.

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© The Japanese Pharmacological Society 2010
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