Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Homeostasis as Regulated by Activated Macrophage. I. Lipopolysaccharide (LPS) from Wheat Flour : Isolation, Purification and Some Biological Activities
Takashi NISHIZAWAHiroyuki INAGAWAHaruyuki OSHIMATakafumi OKUTOMIDaisuke TSUKIOKAMakoto IGUCHIGen-Ichiro SOMADen'ichi MIZUNO
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1992 Volume 40 Issue 2 Pages 479-483

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Abstract

Based on our new concept of ontogenic inflammation, we have sought a substance which can prime macrophage in terms of the endogenous production of tumor necrosis factor (TNF). A lipopolysaccharide (LPSw) was found in wheat flour, purified and characterized. The molecular size of LPSw was about 5kDa sodum dodecyl sulfate-polyacrylamide gel electrophoresis, and it contained 3-deoxy-D-manno-octulosonic acid : 1, hexosamine : 4 and one phosphorus in a single molecule. LPSw can prime macrophage to release TNF when given intradermally, percutaneously or even orally in mice as well as in humans, in exactly the same way as intravenous administration of interferon γ.

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© The Pharmaceutical Society of Japan
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