Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Homeostasis as Regulated by Activated Macrophage. VIII. LPSw (a Lipopolysaccharide from Wheat Fluor) Can Regulate Bone Resorption of Chick Embryo
Kohtaro KAWASHIMAHiroyoshi ENDOTakashi NISHIZAWAHiroyuki INAGAWATakafumi OKUTOMIAkinobu MORIKAWAGen-Ichiro SOMADen'ichi MIZUNO
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1992 Volume 40 Issue 5 Pages 1271-1273

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Abstract

The effect of LPSw (a lipopolysaccharide from wheat fluor) on the bone resorption of 18-d chick embryonic calvaria was examined in an organ culture following the method of Raisz. Bone was prelabeled in culture medium containing 45Ca and chased in a cold medium. On addition of test smples, labeled calcium was released indicating the grade of bone resorption. LPSw (10-100 ng/ml) stimulated bone resorption, showing an effect comparable to parathyroid hormone (PTH) (1 U/ml). PTH at 1 U/ml decreased the total amount of calcium and phosphorus, while LPSw did not. LPSw is thus assumed to simulate bone resorption more actively than PTH.

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© The Pharmaceutical Society of Japan
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