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Borrmann Type 1 Cancer is Associated with a High Recurrence Rate in Locally Advanced Gastric Cancer

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

This study aimed to investigate the clinicopathologic characteristics and outcomes of Borrmann type 1 gastric cancer and evaluate its clinical significance in advanced gastric cancer compared with Borrmann types 2 and 3 cancer.

Methods

Between January 1989 and December 2013, 1949 patients with advanced gastric cancer who underwent curative gastrectomy at our institution were enrolled in the study.

Results

Of the 1949 patients, 59 (3%) exhibited Borrmann type 1 cancer, characterized by a large size, rare serosal invasion, lower lymph node involvement, location in the upper third of the stomach, intestinal type, and differentiated histology. The recurrence rate was higher for Borrmann type 1 than for Borrmann types 2 and 3 cancer. In addition, more than half of the Borrmann type 1 recurrences showed a hematogenous pattern. However, overall survival did not differ significantly among the three cancer types. In the multivariate analysis, Borrmann type 1 cancer, with tumor depth, node metastasis, and vascular invasion, was an independent risk factor associated with recurrence. Particularly, Borrmann type 1 cancer showed a worse prognosis in both overall survival and recurrence-free survival than the other Borrmann types in the upper third of the stomach.

Conclusions

Borrmann type 1 gastric cancer is associated with a higher recurrence rate than Borrmann types 2 and 3, but not with a difference in the overall survival rate.

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Acknowledgments

This research was supported by grants from the National Research Foundation of Korea (Grant Nos. 2012R1A1A1043576 and 2015R1A1A1A05028000).

Disclosure

Authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Ji Hyun Kim MD, Ph.D., Han Hong Lee MD, Ph.D., Ho Seok Seo MD, Yoon Ju Jung MD & Cho Hyun Park MD, Ph.D.

Authors
  1. Ji Hyun Kim MD, Ph.D.
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  2. Han Hong Lee MD, Ph.D.
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  3. Ho Seok Seo MD
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  4. Yoon Ju Jung MD
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  5. Cho Hyun Park MD, Ph.D.
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Corresponding author

Correspondence to Han Hong Lee MD, Ph.D..

Electronic supplementary material

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Supplementary Fig. S1

Distribution of Borrmann types depends on the location of tumor (TIFF 2229 kb)

Supplementary material 2 (DOCX 17 kb)

Supplementary material 3 (DOCX 21 kb)

Supplementary material 4 (DOC 87 kb)

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Kim, J.H., Lee, H.H., Seo, H.S. et al. Borrmann Type 1 Cancer is Associated with a High Recurrence Rate in Locally Advanced Gastric Cancer. Ann Surg Oncol 25, 2044–2052 (2018). https://doi.org/10.1245/s10434-018-6509-3

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  • DOI: https://doi.org/10.1245/s10434-018-6509-3

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