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Prognostic Value of Preoperative Metabolic Tumor Volume and Total Lesion Glycolysis in Patients with Epithelial Ovarian Cancer

  • Gynecologic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are measures of metabolic activity of tumors determined by fluorine-18 fluorodeoxyglucose ([18F]FDG) uptake on PET/CT images. The purpose of this study was to investigate the relationship between functional tumor parameters (MTV and TLG) and clinical outcomes in patients with epithelial ovarian cancer (EOC).

Methods

Fifty-five patients with EOC who had undergone [18F]FDG PET/CT before surgical staging were included in this retrospectively study. For each patient, we determined the highest (SUVmax and SUVavg), the cumulative TLG, and the sum of all MTV, and compared their predictive value of recurrence and the effects of pretreatment functional tumor activity on progression-free interval (PFI).

Results

The median duration of PFI was 11 (range 3–43) months, and 20 patients (36.4%) experienced recurrence. Poor outcome was associated with higher values for both the MTV (P = 0.022, hazard ratio 5.571, 95% confidence interval 1.279–24.272) and the TLG (P = 0.037, hazard ratio 2.967, 95% confidence interval 1.065–8.265). The Kaplan–Meier survival graphs showed a significant difference in PFI between the groups categorized by MTV and TLG, respectively (P = 0.01 for MTV, P = 0.0287 for TLG, log rank test).

Conclusions

Pretreatment metabolic parameters such as MTV and TLG showed statistically significant association with recurrence in patients with EOC. These values can be useful quantitative criteria for disease prognostication in patients with EOC before treatment.

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Disclosure

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Hyun Hoon Chung MD, PhD, Noh-Hyun Park MD, PhD, Yong-Sang Song MD, PhD, Soon-Beom Kang MD, PhD & Jae Weon Kim MD, PhD

  2. Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Hyun Woo Kwon MD, Keon Wook Kang MD, PhD & June-Key Chung MD, PhD

  3. WCU Biomodulation Major, Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea

    Yong-Sang Song MD, PhD

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  1. Hyun Hoon Chung MD, PhD
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  2. Hyun Woo Kwon MD
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  3. Keon Wook Kang MD, PhD
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  4. Noh-Hyun Park MD, PhD
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  6. June-Key Chung MD, PhD
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  7. Soon-Beom Kang MD, PhD
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  8. Jae Weon Kim MD, PhD
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Correspondence to Jae Weon Kim MD, PhD.

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Chung, H.H., Kwon, H.W., Kang, K.W. et al. Prognostic Value of Preoperative Metabolic Tumor Volume and Total Lesion Glycolysis in Patients with Epithelial Ovarian Cancer. Ann Surg Oncol 19, 1966–1972 (2012). https://doi.org/10.1245/s10434-011-2153-x

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  • DOI: https://doi.org/10.1245/s10434-011-2153-x

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