Abstract
Background
The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility.
Materials and Methods
In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms’ association with gastric cancer susceptibility.
Results
We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47–9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups.
Conclusions
Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.
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Acknowledgments
We thank Chia-Wen Tsai, Hsiu-Yun Liang, and Chiao-Lin Lin for their technical assistance. This study was supported by research grants from the China Medical University Hospital (DMR-96-002), Terry Fox Cancer Research Foundation and the National Science Council (NSC 95-2320-B-039-014-MY3, second year).
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C.-F. Chiu and C.-H. Wang contributed equally to this study.
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Chiu, CF., Wang, CH., Wang, CL. et al. A Novel Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Gastric Cancer Susceptibility in Taiwan. Ann Surg Oncol 15, 514–518 (2008). https://doi.org/10.1245/s10434-007-9674-3
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DOI: https://doi.org/10.1245/s10434-007-9674-3