Abstract
Background
After neoadjuvant chemotherapy, women with locally advanced breast cancer (LABC) undergo a modified radical mastectomy or lumpectomy with axillary lymph node dissection (ALND) and radiotherapy. Sentinel lymphadenectomy (SL) is accepted for axillary evaluation in early breast cancer. We assessed the feasibility and predictive value of SL after neoadjuvant chemotherapy.
Methods
Eligible women received neoadjuvant therapy for LABC and were scheduled to undergo a definitive surgical procedure. Vital blue dye SL was attempted followed by level I and II axillary dissection.
Results
SL was successful in 29 of 34 patients (detection rate, 85%). Thirteen patients (45%) had positive nodes, and eight (28%) had negative nodes on both SL and ALND. In five patients (17%), the sentinel node was the only positive node identified. Overall, there was a 90% concordance between SL and ALND. The false-negative rate and negative predictive value were 14% and 73%, respectively. Among the subgroup without inflammatory cancer, the detection and concordance rates were 89% and 96%, respectively. The false-negative rate was 6%, and the negative predictive value was 88%.
Conclusions
SL after neoadjuvant chemotherapy may reliably predict axillary staging except in inflammatory breast cancer. Further studies are required to assess the utility of SL as the only mode of axillary evaluation in these women.
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References
Morrow M, Harris JR. Local management of invasive breast cancer. In: Harris JR, Lippman ME, Morrow, M, Osborne CK, eds.Diseases of The Breast. Philadelphia: Lippincott Williams & Wilkins, 200:515–60.
Esteva FJ, Hortobagyi GN. Locally advanced breast cancer.Hemotol Oncol Clin North Am 1999;13:457–72, vii.
Bonadonna G, Valagussa P, Brambilla C, et al. Primary chemotherapy in operable breast cancer: eight-year experience at the Milan Cancer Institute.J Clin Oncol 1998;16:93–100.
Fisher B, Bryant J, Wolmark N, et al. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer.J Clin Oncol 1998;16:2672–85.
Hellman S, Harris JR. Natural history of breast cancer. In: Harris J, Lippman M, Morrow M, Osborne CK, eds.Diseases of the Breast. Philadelphia: Lippincott Williams & Wilkins, 2000:407–23.
Meric F, Mirza NQ, Buzdar AU, et al. Prognostic implications of pathological lymph node status after preoperative chemotherapy for operable T3N0M0 breast cancer.Ann Surg Oncol 2000;7:435–40.
Ivens D, Hoe AL, Podd TJ, Hamilton CR, Taylor I, Royle GT. Assessment of morbidity from complete axillary dissection.Br J Cancer 1992;66:136–8.
Morrow M. Role of axillary dissection in breast cancer management.Ann Surg Oncol 1996;3:233–4.
Kuehn T, Klauss W, Darsow M, et al. Long-term morbidity following axillary dissection in breast cancer patients—clinical assessment, significance for life quality and the impact of demographic, oncologic and therapeutic factors.Breast Cancer Res Treat 2000;64:275–86.
Erickson VS, Pearson ML, Ganz PA, Adams J, Kahn KL. Arm edema in breast cancer patients.J Natl Cancer Inst 2001;93:96–111.
Cox CE, Pendas S, Cox JM et al. Guidelines for sentinel node biopsy and lymphatic mapping of patients with breast cancer.Ann Surg 1998;227:645–51; discussion, 651–3.
Krag D, Weaver D, Ashikaga T, et al. The sentinel nodel in breast cancer—a multicenter validation study.N Engl J Med 1998;339:941–6.
Giuliano AE, Jones RC, Brennan M, Statman R. Sentinel lymphadenectomy in breast cancer.J Clin Oncol 1997;15:2345–50.
Veronesi U, Paganelli G, Viale G, et al. Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series.J Natl Cancer Inst 1999;91:368–73.
Hsueh EC, Hansen N, Giuliano AE. Intraoperative lymphatic mapping and sentinel lymph node dissection in breast cancer.CA Cancer J Clin 2000;50:279–91.
Snedecor G, Cochran W.Statistical Methods. 8th ed. Sect. 7.8. Ames, IA: Iowa State University Press, 1989:121.
Margetts BM, Nelson M.Design Concepts in Nutritional Epidemiology. Vol. sect. 1.3.1 Oxford: Oxford University Press, 1991:23–4.
Risks and risk differences (chapt. 28). In:SAS/STAT® Users' Guide, Version 8. Cary, NC: SAS Institute Inc., 1999:1299–300.
Morrow M, White J, Moughan J, et al. Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma.J Clin Oncol 2001;19:2254–62.
Vlastos G, Mirza NQ, Lenert JT, et al. The feasibility of minimally invasive surgery for stage IIA, IIB, and IIIA breast carcinoma patients after tumor downstaging with induction chemotherapy.Cancer 2000;88:1417–24.
Swain SM. Locally advanced noninflammatory breast cancer.Cancer Invest 1999;17:211–9.
Fisher B, Mamounas E. Preoperative chemotherapy: a model for studying the biology and therapy of primary breast cancer.J Clin Oncol 1995;13:537–40.
Wolff AC, Davidson NE. Primary systemic therapy in operable breast cancer.J Clin Oncol 2000;18:1558–69.
Breslin TM, Cohen L, Sahin A, et al. Sentinel lymph node biopsy is accurate after neoadjuvant chemotherapy for breast cancer.J Clin Oncol 2000;18:3480–6.
Nason KS, Anderson BO, Byrd DR, et al. Increased false negative sentinel node biopsy rates after preoperative chemotherapy for invasive breast carcinoma.Cancer 2000;89:2187–94.
Ewing C, Tsangaris T, Pennanen M, Buras R, Lage J. Frozen section discordance on axillary sentinel lymph node biopsies [Abstract].Breast Cancer Res Treat 1999;57:37.
Weiser MR, Montgomery LL, Susnik B, Tan LK, Borgen PI, Cody HS. Is routine intraoperative frozen-section examination of sentinel lymph nodes in breast cancer worthwhile?.Ann Surg Oncol 2000;7:651–5.
Singletary SE. Techniques of surgery. In: Harris JR, Lippman ME, Morrow M, Osborne CK, eds.Diseases of the Breast. Philadelphia: Lippincott Williams & Wilkins, 2000:577–88.
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Stearns, V., Ewing, C.A., Slack, R. et al. Sentinel lymphadenectomy after neoadjuvant chemotherapy for breast cancer may reliably represent the axilla except for inflammatory breast cancer. Annals of Surgical Oncology 9, 235–242 (2002). https://doi.org/10.1007/BF02573060
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DOI: https://doi.org/10.1007/BF02573060