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Results of R0 Resection for Colorectal Liver Metastases Associated With Extrahepatic Disease

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Abstract

Background: Extrahepatic malignant disease has always been considered an absolute contraindication to hepatectomy for colorectal liver metastases. This study reports the long-term outcome and prognostic factors of patients undergoing extrahepatic disease resection simultaneously with hepatectomy for liver metastases.

Methods: From January 1987 to January 2001, 75 patients underwent a complete R0 resection of extrahepatic disease simultaneously with hepatectomy for colorectal liver metastases. They were inscribed in a registry and then prospectively followed up. They represented 25% of the 294 patients who underwent an R0 hepatectomy for colorectal liver metastases during the same period.

Results: The mortality rate was 2.7%, and morbidity was 25%. After a median follow-up of 4.9 years (range, 1.7–13.4 years), the overall 3- and 5-year survival rates were 45% and 28%, respectively. By using a Cox model, there was a significant difference in survival between patients with single versus multiple sites of extrahepatic disease. Also, the presence of more than five liver metastases was a significant parameter.

Conclusions: Extrahepatic disease in colorectal cancer patients with liver metastases should no longer be considered as a contraindication to hepatectomy. However, this intended R0 resection cannot be performed in 50% of laparotomized patients, and negative prognostic factors for surgery include the presence of multiple extrahepatic disease sites or more than five liver metastases.

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Authors and Affiliations

  1. Departments of Surgical Oncology, Gustave Roussy Institute, Villejuif, France

    Dominique Elias MD, PhD, Lucas Sideris MD, FRCSC, Marc Pocard MD, PhD, Jean-Francois Ouellet MD, FRCSC & Philippe Lasser MD

  2. Departments of Medical Oncology, Gustave Roussy Institute, Villejuif, France

    Valérie Boige MD & Michel Ducreux MD

  3. Departments of Biostatistics and Epidemiology, Gustave Roussy Institute, Villejuif, France

    Jean-Pierre Pignon MD, PhD

  4. Department of Surgery, Division of Surgical Oncology, Gustave Roussy Institute, Rue Camille Desmoulins, 94805, Villejuif CEDEX, France

    Dominique Elias MD, PhD

Authors
  1. Dominique Elias MD, PhD
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  2. Lucas Sideris MD, FRCSC
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  3. Marc Pocard MD, PhD
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  4. Jean-Francois Ouellet MD, FRCSC
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  5. Valérie Boige MD
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  6. Philippe Lasser MD
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  7. Jean-Pierre Pignon MD, PhD
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  8. Michel Ducreux MD
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Correspondence to Dominique Elias MD, PhD.

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Elias, D., Sideris, L., Pocard, M. et al. Results of R0 Resection for Colorectal Liver Metastases Associated With Extrahepatic Disease. Ann Surg Oncol 11, 274–280 (2004). https://doi.org/10.1245/ASO.2004.03.085

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  • DOI: https://doi.org/10.1245/ASO.2004.03.085

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