Epithelial-Mesenchymal Transition—A Hallmark of Breast Cancer Metastasis
Epithelial-mesenchymal transition (EMT) is a highly conserved cellular program that converts polarized, immotile epithelial cells to migratory mesenchymal cells. in addition, emt was initially recognized as a key step for morphogenesis during embryonic development. emerging evidences
indicate that this important developmental program promotes metastasis, drug resistance, and tumor recurrence, features that are associated with a poor clinical outcome for patients with breast cancer. therefore, better understanding of regulation and signaling pathways in emt is essential
to develop novel targeted therapeutics. in this review, we present updated developments underlying emt in tumor progression and metastasis, and discuss the challenges remaining in breast cancer research.
Keywords: BREAST CANCER; EMT; METASTASIS; SIGNALING PATHWAY; SNAIL
Document Type: Research Article
Publication date: 01 March 2013
- World Journal of Cancer Research publishes original articles describing significant new findings in any area related to basic and clinical cancer research. These include studies of cancer related genes, molecules, drugs, cancer cell lines, tumorigenesis, cancer prevention, cancer progression and metastasis, cancer diagnosis, cancer treatment, cancer animal models, human cancer samples as well as cancer patients and all other cancer research related areas.
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