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Abstract

The purpose of this review is to provide a sufficiently detailed perspective on epidemiologic studies of primary brain tumors to encourage multidisciplinary etiologic and prognostic studies among surgeons, neuro-oncologists, epidemiologists, and molecular scientists. Molecular tumor markers that predict survival and treatment response are being identified with hope of even greater gains in this area from emerging array technologies. Regarding risk factors, studies of inherited susceptibility and constitutive polymorphisms in genes pertinent to carcinogenesis (for example, DNA repair and detoxification genes and mutagen sensitivity) have revealed provocative findings. Inverse associations of the history of allergies with glioma risk observed in 3 large studies and reports of inverse associations of glioma with common infections suggest a possible role of immune factors in glioma genesis or progression. Studies continue to suggest that brain tumors might result from workplace, dietary, and other personal and residential exposures, but studies of cell phone use and power frequency electromagnetic fields have found little to support a causal connection with brain tumors; caveats remain. The only proven causes of brain tumors (that is, rare hereditary syndromes, therapeutic radiation, and immune suppression giving rise to brain lymphomas) account for a small proportion of cases. Progress in understanding primary brain tumors might result from studies of well-defined histologic and molecular tumor types incorporating assessment of potentially relevant information on subject susceptibility and environmental and noninherited endogenous factors (viruses, radiation, and carcinogenic or protective chemical exposures through diet, workplace, oxidative metabolism, or other sources). Such studies will require the cooperation of researchers from many disciplines.

References

ACS (American Cancer Society). (

1998
)
Cancer Facts and Figures 1998
. Atlanta: American Cancer Society.

Ahlbom, A., Navier, I.L., Norell, S., Olin, R., and Spannare, B. (

1986
) Nonoccupational risk indicators for astrocytomas in adults.
Am. J. Epidemiol.
124
,
334
-337.

Aldape, K., Simmons, M.L., Davis, R.L., Miike, R., Wiencke, J., Barger, G., Lee, M., Chen, P., and Wrensch, M. (

2000
) Discrepancies in diagnoses of neuroepithelial neoplasms: The San Francisco Bay Area Adult Glioma Study.
Cancer
88
,
2342
-2349.

Alexander, V., and DiMarco, J.H. (

2001
) Reappraisal of brain tumor risk among U.S. nuclear workers: A 10–year review.
Occup. Med.
16
,
289
-315.

Ames, B.N., Shigenaga, M.K., and Hagen, T.M. (

1993
) Oxidants, antioxidants, and the degenerative diseases of aging.
Proc. Natl. Acad. Sci. U.S.A.
90
,
7915
-7922.

Aronson, K.J., Tomlinson, G.A., and Smith, L. (

1994
) Mortality among fire fighters in metropolitan Toronto.
Am. J. Ind. Med.
26
,
89
-101.

Berleur, M.P., and Cordier, S. (

1995
) The role of chemical, physical, or viral exposures and health factors in neurocarcinogenesis: Implications for epidemiologic studies of brain tumors.
Cancer Causes Control
6
,
240
-256.

Bithell, J.F., Draper, G.J., and Gorbach, P.D. (

1973
) Association between malignant disease in children and maternal virus infections.
Br. Med. J.
1
,
706
-708.

Blair, A., Saracci, R., Stewart, P.A., Hayes, R.B., and Shy, C. (

1990
) Epidemiologic evidence on the relationship between formaldehyde exposure and cancer.
Scand. J. Work Environ. Health
16
,
381
-393.

Blettner, M., and Schlehofer, B. (

1999
) Is there an increased risk of leukemia, brain tumors or breast cancer after exposure to high-frequency radiation? Review of methods and results of epidemiologic studies [German].
Med. Klin.
94
,
150
-158.

Blot, W.J., Henderson, B.E., and Boice, J.D., Jr. (

1999
) Childhood cancer in relation to cured meat intake: Review of the epidemiological evidence.
Nutr. Cancer
34
,
111
-118.

Boffetta, P., Tredaniel, J., and Greco, A. (

2000
) Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: A meta-analysis.
Environ. Health Perspect
.
108
,
73
-82.

Bohnen, N.I., and Kurland, L.T. (

1995
) Brain tumor and exposure to pesticides in humans: A review of the epidemiologic data.
J. Neurol. Sci.
132
,
110
-121.

Bondy, M., and Ligon, B.L. (

1996
) Epidemiology and etiology of intracranial meningiomas: A review.
J. Neurooncol.
29
,
197
-205.

Bondy, M., Wiencke, J., Wrensch, M., and Kyritsis, A.P. (

1994
) Genetics of primary brain tumors: A review.
J. Neurooncol.
18
,
69
-81.

Bondy, M.L., Kyritsis, A.P., Gu, J., de Andrade, M., Cunningham, J., Levin, V.A., Bruner, J.M., and Wei, Q. (

1996
) Mutagen sensitivity and risk of gliomas: A case-control analysis.
Cancer Res.
56
,
1484
-1486.

Bondy, M.L., Wang, L.E., El-Zein, R., de Andrade, M., Selvan, M.S., Bruner, J.M., Levin, V.A., Yung, W.K.A., Adatto, P., and Wei, Q. (

2001
) Gamma-radiation sensitivity and risk of glioma.
J. Natl. Cancer Inst.
93
,
1553
-1557.

Brenner, A.V., Linet, M.S., Fine, H.A., Shapiro, W.R., Selker, R.G., Black, P.M., and Inskip, P.D. (

2002
) History of allergies and autoimmune diseases and risk of brain tumors in adults.
Int. J. Cancer
99
,
252
-259.

Brinton, L.A., Lubin, J.H., Burich, M.C., Colton, T., Brown, S.L., and Hoover, R.N. (

2001
) Cancer risk at sites other than the breast following augmentation mammoplasty.
Ann. Epidemiol.
11
,
248
-256.

Bunin, G. (

2000
) What causes childhood brain tumors? Limited knowledge, many clues.
Pediatr. Neurosurg.
32
,
321
-326.

Burch, J.D., Craib, K.J., Choi, B.C., Miller, A.B., Risch, H.A., and Howe, G.R. (

1987
) An exploratory case-control study of brain tumors in adults.
J. Natl. Cancer Inst.
78
,
601
-609.

Burnett, C., Robinson, C., and Walker, J. (

1999
) Cancer mortality in health and science technicians.
Am. J. Ind. Med.
36
,
155
-158.

Caggana, M., Kilgallen, J., Conroy, J.M., Wiencke, J.K., Kelsey, K.T., Miike, R., Chen, P., and Wrensch, M.R. (

2001
) Associations between ERCC2 polymorphisms and gliomas.
Cancer Epidemiol. Biomarkers Prev.
10
,
355
-360.

Cairncross, J.G., Ueki, K., Zlatescu, M.C., Lisle, D.K., Finkelstein, D.M., Hammond, R.R., Silver, J.S., Stark, P.C., Macdonald, D.R., Ino, Y., Ramsay, D.A., and Louis, D.N. (

1998
) Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.
J. Natl. Cancer Inst.
90
,
1473
-1479.

Cantor, K.P., Lynch, C.F., Hildesheim, M.E., Dosemeci, M., Lubin, J., Alavanja, M., and Craun, G. (

1999
) Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer.
Am. J. Epidemiol.
150
,
552
-560.

Carozza, S.E., Wrensch, M., Miike, R., Newman, B., Olshan, A.F., Savitz, D.A., Yost, M., and Lee, M. (

2000
) Occupation and adult glioma.
Am. J. Epidemiol.
152
,
838
-846.

CBTRUS (Central Brain Tumor Registry of the United States) (

1998
)
1997 Annual Report
. Chicago: Central Brain Tumor Registry of the United States.

CBTRUS (Central Brain Tumor Registry of the United States) (

2000
)
Statistical Report: Primary Brain Tumors in the United States 1992–1997
. Chicago: Central Brain Tumor Registry of the United States.

CDC (Centers for Disease Control) (

1990
)
Guidelines for Investigating Clusters of Health Events: Appendix: Summary of Methods for Statistically Assessing Clusters of Health Events
. Atlanta: CDC.

Chen, P., Wiencke, J., Aldape, K., Kesler-Diaz, A., Miike, R., Kelsey, K., Lee, M., Liu, J., and Wrensch, M. (

2000
) Association of an ERCC1 polymorphism with adult-onset glioma.
Cancer Epidemiol Biomarkers Prev.
9
,
843
-847.

Chen, P., Aldape, K., Wiencke, J.K., Kelsey, K.T., Miike, R., Davis, R.L., Liu, J., Kesler-Diaz, A., Takahashi, M., and Wrensch, M. (

2001
) Ethnicity delineates different genetic pathways in malignant glioma.
Cancer Res.
61
,
3949
-3954.

Choi, N.W., Schuman, L.M., and Gullen, W.H. (

1970
) Epidemiology of primary central nervous system neoplasms. II. Case-control study.
Am. J. Epidemiol.
91
,
467
-485.

Clemmesen, J., and Hjalgrim-Jensen, S. (

1978
) Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.
Ecotoxicol. Environ. Saf.
1
,
457
-470.

Cocco, P., Heineman, E.F., and Dosemeci, M. (

1999
) Occupational risk factors for cancer of the central nervous system (CNS) among US women.
Am. J. Ind. Med.
36
,
70
-74.

Codd, M.B., Kurland, L.T., O'Fallon, W.M., Beard, C.M., and Cascino, T.L. (

1990
) Case-control study of neuroepithelial tumors in Rochester, Minnesota, 1950–1977.
Neuroepidemiology
9
,
17
-26.

Cooper, S.P., Labarthe, D., Downs, T., Burau, K., Whitehead, L., Vernon, S., Spitz, M., New, B., and Sigurdson, A. (

1997
) Cancer mortality among petroleum refinery and chemical manufacturing workers in Texas.
J. Environ. Pathol. Toxicol. Oncol.
16
,
1
-14.

Cuomo, L., Trivedi, P., Cardillo, M.R., Gagliardi, F.M., Vecchione, A., Caruso, R., Calogero, A., Frati, L., Faggioni, A., and Ragona, G. (

2001
) Human herpesvirus 6 infection in neoplastic and normal brain tissue.
J. Med. Virol.
63
,
45
-51.

Curran, W.J., Jr., Scott, C.B., Horton, J., Nelson, J.S., Weinstein, A.S., Fischbach, A.J., Chang, C.H., Rotman, M., Asbell, S.O., Krisch, R.E., and Nelson, D.F. (

1993
) Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials.
J. Natl. Cancer Inst.
85
,
704
-710.

Davis, F.G., and McCarthy, B.J. (

2000
) Epidemiology of brain tumors.
Curr. Opin. Neurol.
13
,
635
-640.

Davis, F.G., and Preston-Martin, S. (

1998
) Epidemiology: Incidence and survival. In: Bigner, D.D., McLendon, R.E., and Bruner, J.M. (Eds.),
Russell and Rubinstein's Pathology of Tumors of the Nervous System. Sixth edition
. London: Oxford University Press. pp.
5
-45.

Davis, F.G., Bruner, J.M., and Surawicz, T.S. (

1997
) The rationale for standardized registration and reporting of brain and central nervous system tumors in population-based cancer registries.
Neuroepidemiology
16
,
308
-316.

Davis, F.G., Freels, S., Grutsch, J., Barlas, S., and Brem, S. (

1998
) Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: An analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973–1991.
J. Neurosurg.
88
,
1
-10.

Davis, F.G., McCarthy, B., and Jukich, P. (

1999a
) The descriptive epidemiology of brain tumors.
Neuroimaging Clin. N. Am.
9
,
581
-594.

Davis, F.G., McCarthy, B.J., Freels, S., Kupelian, V., and Bondy, M.L. (

1999b
) The conditional probability of survival of patients with primary malignant brain tumors: Surveillance, epidemiology, and end results (SEER) data.
Cancer
85
,
485
-491.

Davis, F.G., Kupelian, V., Freels, S., McCarthy, B., and Surawicz, T. (

2001
) Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups.
Neuro-oncol.
3
,
152
-158.

Davis, S., Kaune, W.T., Mirick, D.K., Chen, C., and Stevens, R.G. (

2001
) Residential magnetic fields, light-at-night, and nocturnal urinary 6–sulfatoxymelatonin concentration in women.
Am. J. Epidemiol.
154
,
591
-600.

de Andrade, M., Barnholtz, J.S., Amos, C.I., Adatto, P., Spencer, C., and Bondy, M.L. (

2001
) Segregation analysis of cancer in families of glioma patients.
Genet. Epidemiol.
20
,
258
-270.

Del Valle, L., Gordon, J., Assimakopoulou, M., Enam, S., Geddes, J.F., Varakis, J.N., Katsetos, C.D., Croul, S., and Khalili, K. (

2001
) Detection of JC virus DNA sequences and expression of the viral regulatory protein T-antigen in tumors of the central nervous system.
Cancer Res.
61
,
4287
-4293.

Delzell, E., Beall, C., Rodu, B., Lees, P.S., Breysse, P.N., and Cole, P. (

1999
) Case-series investigation of intracranial neoplasms at a petrochemical research facility.
Am. J. Ind. Med.
36
,
450
-458.

Demers, P.A., Vaughan, T.L., and Schommer, R.R. (

1991
) Occupation, socioeconomic status, and brain tumor mortality: A death certificate-based case-control study.
J. Occup. Med.
33
,
1001
-1006.

Demers, P.A., Heyer, N.J., and Rosenstock, L. (

1992
) Mortality among firefighters from three northwestern United States cities.
Br. J. Ind. Med.
49
,
664
-670.

Demers, P.A., Checkoway, H., Vaughan, T.L., Weiss, N.S., Heyer, N.J., and Rosenstock, L. (

1994
) Cancer incidence among firefighters in Seattle and Tacoma, Washington (United States).
Cancer Causes Control
5
,
129
-135.

Deschamps, S., Momas, I., and Festy, B. (

1995
) Mortality amongst Paris firefighters.
Eur. J. Epidemiol.
11
,
643
-646.

Devesa, S.S., Grauman, D.G., Blot, W.J., Pennello, G., Hoover, R.N., and Fraumeni, J.F. (

1999
)
Atlas of Cancer Mortality in the United States, 1950–94
. Washington, DC: National Institute of Health, National Cancer Institute.

Divine, B.J., and Hartman, C.M. (

2000
) Update of a study of crude oil production workers 1946–94.
Occup. Environ. Med.
57
,
411
-417.

Divine, B.J., Hartman, C.M., and Wendt, J.K. (

1999
) Update of the Texaco mortality study 1947–93. I. Analysis of overall patterns of mortality among refining, research, and petrochemical workers.
Occup. Environ. Med.
56
,
167
-173.

Elexpuru-Camiruaga, J., Buxton, N., Kandula, V., Dias, P.S., Campbell, D., McIntosh, J., Broome, J., Jones, P., Inskip, A., Alldersea, J., Fryer, A.A., and Strange, R.C. (

1995
) Susceptibility to astrocytoma and meningioma: Influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.
Cancer Res.
55
,
4237
-4239.

Farwell, J.R., Dohrmann, G.J., and Flannery, J.T. (

1984
) Medulloblastoma in childhood: An epidemiological study.
J. Neurosurg.
61
,
657
-664.

Feychting, M., Floderus, B., and Ahlbom, A. (

2000
) Parental occupational exposure to magnetic fields and childhood cancer (Sweden).
Cancer Causes Control
11
,
151
-156.

Firth, H.M., Cooke, K.R., and Herbison, G.P. (

1996
) Male cancer incidence by occupation: New Zealand, 1972–1984.
Int. J. Epidemiol.
25
,
14
-21.

Fisher, J.L., Schwartzbaum, J.A., and Johnson, C.C. (

2000
) Cold/influenza infection, influenza vaccination, and risk of adult glioma.
Am. J. Epidemiol.
151
,
S29
. (Abstract)

Fisher, S.G., Weber, L., and Carbone, M. (

1999
) Cancer risk associated with simian virus 40 contaminated polio vaccine.
Anticancer Res.
19
,
2173
-2180.

Floderus, B., Stenlund, C., and Persson, T. (

1999
) Occupational magnetic field exposure and site-specific cancer incidence: A Swedish cohort study.
Cancer Causes Control
10
,
323
-332.

Fremgen, A.M., Bland, K.I., McGinnis, L.S., Jr., Eyre, H.J., McDonald, C.J., Menck, H.R., and Murphy, G.P. (

1999
) Clinical highlights from the National Cancer Data Base, 1999.
CA: Cancer J. Clin.
49
,
145
-158.

Gao, L., Liu, L., van Meyel, D., Cairncross, G., Forsyth, P., Kimmel, D., Jenkins, R.B., Lassam, N.J., and Hogg, D. (

1997
) Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma.
Clin. Cancer Res.
3
,
977
-981.

Gavin, P., and Yogev, R. (

1999
) Central nervous system abnormalitiesin pediatric human immunodeficiency virus infection.
Pediatr. Neurosurg.
31
,
115
-123.

Geissler, E., and Staneczek, W. (

1988
) SV40 and human brain tumors.
Arch. Geschwulstforschung
.
58
,
129
-134.

Glaser, S.L., Satariano, E., Leung, R.W., Prehn, A.W., Cady, C.M., and West, D.W. (Eds.) (

1996
)
Cancer Incidence by Race/Ethnicity in the San Francisco Bay Area: Twenty Years of Cancer Reporting 1973–1992
. Union City, Calif.: Northern California Cancer Center.

Golden, A.L., Markowitz, S.B., and Landrigan, P.J. (

1995
) The risk of cancer in firefighters.
Occup. Med.
10
,
803
-820.

Grossman, S.A., Osman, M., Hruban, R., and Piantadosi, S. (

1999
) Central nervous system cancers in first-degree relatives and spouses.
Cancer Invest
.
17
,
299
-308.

Grotzer, M.A., Janss, A.J., Phillips, P.C., and Trojanowski, J.Q. (

2000
) Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain tumors.
Klin. Padiatr.
212
,
196
-199.

Grotzer, M.A., Geoerger, B., Janss, A.J., Zhao, H., Rorke, L.B., and Phillips, P.C. (

2001
) Prognostic significance of Ki-67 (MIB-1) proliferation index in childhood primitive neuroectodermal tumors of the central nervous system.
Med. Pediatr. Oncol.
36
,
268
-273.

Grovas, A., Fremgen, A., Rauck, A., Ruymann, F.B., Hutchinson, C.L., Winchester, D.P., and Menck, H.R. (

1997
) The National Cancer Data Base report on patterns of childhood cancers in the United States.
Cancer
80
,
2321
-2332.

Guidotti, T.L. (

1995
) Occupational mortality among firefighters: Assessing the association.
J. Occup. Environ. Med.
37
,
1348
-1356.

Gundestrup, M., and Storm, H.H. (

1999
) Radiation-induced acute myeloid leukaemia and other cancers in commercial jet cockpit crew: A population-based cohort study.
Lancet
354
,
2029
-2031.

Gurney, J.G., Preston-Martin, S., McDaniel, A.M., Mueller, B.A., and Holly, E.A. (

1996
) Head injury as a risk factor for brain tumors in children: Results from a multicenter case-control study.
Epidemiology
7
,
485
-489.

Gurney, J.G., Wall, D.A., Jukich, P.J., and Davis, F.G. (

1999
) The contribution of nonmalignant tumors to CNS tumor incidence rates among children in the United States.
Cancer Causes Control
10
,
101
-105.

Hagel, C., Krog, B., Laas, R., and Stavrou, D.K. (

1999
) Prognostic relevance of TP53 mutations, p53 protein, Ki-67 index and conventional histological grading in oligodendrogliomas.
J. Exp. Clin. Cancer Res.
18
,
305
-309.

Hagmar, L., Akesson, B., Nielsen, J., Andersson, C., Lindén, K., Attewell, R., and Möller, T. (

1990
) Mortality and cancer morbidity in workers exposed to low levels of vinyl chloride monomer at a polyvinyl chloride processing plant.
Am. J. Ind. Med.
17
,
553
-565.

Hardell, L., Nasman, A., Pahlson, A., Hallquist, A., and Hansson Mild, K. (

1999
) Use of cellular telephones and the risk for brain tumours: A case-control study.
Int. J. Oncol.
15
,
113
-116.

Hardell, L., Mild, K.H., Pahlson, A., and Hallquist, A. (

2001
) Ionizing radiation, cellular telephones and the risk for brain tumours.
Eur. J. Cancer Prev.
10
,
523
-529.

Helseth, A. (

1995
) The incidence of primary central nervous system neoplasms before and after computerized tomography availability.
J. Neurosurg.
83
,
999
-1003.

Hemminki, K., Li, X., Vaittinen, P., and Dong, C. (

2000
) Cancers in the first-degree relatives of children with brain tumours.
Br. J. Cancer
83
,
407
-411.

Hjalmars, U., Kulldorff, M., Wahlqvist, Y., and Lannering, B. (

1999
) Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973–1992: A population-based study of pediatric brain tumors.
Cancer
85
,
2077
-2090.

Hodges, L.C., Smith, J.L., Garrett, A., and Tate, S. (

1992
) Prevalence of glioblastoma multiforme in subjects with prior therapeutic radiation.
J. Neurosci. Nurs.
24
,
79
-83.

Holly, E.A., Bracci, P.M., Mueller, B.A., and Preston-Martin, S. (

1998
) Farm and animal exposures and pediatric brain tumors: Results from the United States West Coast Childhood Brain Tumor Study.
Cancer Epidemiol. Biomarkers Prev.
7
,
797
-802.

Horn, B., Heideman, R., Geyer, R., Pollack, I., Packer, R., Goldwein, J., Tomita, T., Schomberg, P., Ater, J., Luchtman-Jones, L., Rivlin, K., Lamborn, K., Prados, M., Bollen, A., Berger, M., Dahl, G., McNeil, E., Patterson, K., Shaw, D., Kubalik, M., and Russo, C. (

1999
) A multi-institutional retrospective study of intracranial ependymoma in children: Identification of risk factors.
J. Pediatr. Hematol. Oncol.
21
,
203
-211.

Hu, J., La Vecchia, C., Negri, E., Chatenoud, L., Bosetti, C., Jia, X., Liu, R., Huang, G., Bi, D., and Wang, C. (

1999
) Diet and brain cancer in adults: A case-control study in northeast China.
Int. J. Cancer
81
,
20
-23.

Hu, J., Mao, Y., and Ugnat, A.M. (

2000
) Parental cigarette smoking, hard liquor consumption and the risk of childhood brain tumors—a case-control study in northeast China.
Acta Oncol.
39
,
979
-984.

Huncharek, M., and Kupelnick, B. (

2000
) Epidermal growth factor receptor gene amplification as a prognostic marker in glioblastoma multiforme: Results of a meta-analysis.
Oncol. Res.
12
,
107
-112.

Inskip, P.D., Linet, M.S., and Heineman, E.F. (

1995
) Etiology of brain tumors in adults.
Epidemiol. Rev.
17
,
382
-414.

Inskip, P.D., Mellemkjaer, L., Gridley, G., and Olsen, J.H. (

1998
) Incidence of intracranial tumors following hospitalization for head injuries (Denmark).
Cancer Causes Control
9
,
109
-116.

Inskip, P.D., Tarone, R.E., Hatch, E.E., Wilcosky, T.C., Shapiro, W.R., Selker, R.G., Fine, H.A., Black, P.M., Loeffler, J.S., and Linet, M.S. (

2001
) Cellular-telephone use and brain tumors.
N. Engl. J. Med.
344
,
79
-86.

Irvine, D., and Davies, D.M. (

1999
) British Airways flightdeck mortality study, 1950–1992.
Aviat. Space Environ. Med.
70
,
548
-555.

James, C.D., Smith, J.S., and Jenkins, R.B. (

2002
) Genetic and molecular basis of primary central nervous system tumors. In: Levin, V. (Ed.),
Cancer in the Nervous System. Second edition
. New York: Oxford University Press. pp.
239
-251.

Johansen, C., and Olsen, J.H. (

1999
) Risk of cancer among Danish electricity workers: A cohort study [Danish].
Ugeskr. Laeger
161
,
2079
-2085.

Johansen, C., Boice, J.D., Jr., McLaughlin, J.K., and Olsen, J.H. (

2001
) Cellular telephones and cancer—a nationwide cohort study in Denmark.
J. Natl. Cancer Inst.
93
,
203
-207.

Jukich, P.J., McCarthy, B.J., Surawicz, T.S., Freels, S., and Davis, F.G. (

2001
) Trends in incidence of primary brain tumors in the United States, 1985–1994. Neuro-oncol. [serial online], Doc. 00–055, June 5, 2001. URL http://neuro-oncology.mc.duke.edu.
Neuro-oncol.
3
,
141
-151.

Kaplan, S., Novikov, I., and Modan, B. (

1997
) Nutritional factors in the etiology of brain tumors: Potential role of nitrosamines, fat, and cholesterol.
Am. J. Epidemiol.
146
,
832
-841.

Karak, A.K., Singh, R., Tandon, P.N., and Sarkar, C. (

2000
) A comparative survival evaluation and assessment of interclassification concordance in adult supratentorial astrocytic tumors.
Pathol. Oncol. Res.
6
,
46
-52.

Karlsson, P., Holmberg, E., Lundell, M., Mattsson, A., Holm, L.E., and Wallgren, A. (

1998
) Intracranial tumors after exposure to ionizing radiation during infancy: A pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma.
Radiat. Res.
150
,
357
-364.

Kelsey, K.T., Wrensch, M., Zuo, Z.F., Miike, R., and Wiencke, J.K. (

1997
) A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors.
Pharmacogenetics
7
,
463
-468.

Kheifets, L.I., Afifi, A.A., Buffler, P.A., and Zhang, Z.W. (

1995
) Occupational electric and magnetic field exposure and brain cancer: A meta-analysis.
J. Occup. Environ. Med.
37
,
1327
-1341.

Kheifets, L.I., Sussman, S.S., and Preston-Martin, S. (

1999
) Childhood brain tumors and residential electromagnetic fields (EMF).
Rev. Environ. Contam. Toxicol.
159
,
111
-129.

Khuder, S.A., Mutgi, A.B., and Schaub, E.A. (

1998
) Meta-analyses of brain cancer and farming.
Am. J. Ind. Med.
34
,
252
-260.

Kleihues, P., and Ohgaki, H. (

2000
) Phenotype vs genotype in the evolution of astrocytic brain tumors.
Toxicol. Pathol.
28
,
164
-170.

Krewski, D., Byus, C.V., Glickman, B.W., Lotz, W.G., Mandeville, R., McBride, M.L., Prato, F.S., and Weaver, D.F. (

2001
) Recent advances in research on radiofrequency fields and health.
J. Toxicol. Environ. Health B Crit. Rev.
4
,
145
-159.

Kristensen, P., Andersen, A., Irgens, L.M., Bye, A.S., and Sundheim, L. (

1996
) Cancer in offspring of parents engaged in agricultural activities in Norway: Incidence and risk factors in the farm environment.
Int. J. Cancer
65
,
39
-50.

Krynska, B., Del Valle, L., Croul, S., Gordon, J., Katsetos, C.D., Carbone, M., Giordano, A., and Khalili, K. (

1999
) Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas.
Proc. Natl. Acad. Sci. U.S.A.
96
,
11519
-11524.

Kyritsis, A.P., Bondy, M.L., Xiao, M., Berman, E.L., Cunningham, J.E., Lee, P.S., Levin, V.A., and Saya, H. (

1994
) Germline p53 gene mutations in subsets of glioma patients.
J. Natl. Cancer Inst.
86
,
344
-349.

Lee, M., Wrensch, M., and Miike, R. (

1997
) Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA).
Cancer Causes Control
8
,
13
-24.

Legler, J.M., Ries, L.A., Smith, M.A., Warren, J.L., Heineman, E.F., Kaplan, R.S., and Linet, M.S. (

1999
) Cancer surveillance series [corrected]: Brain and other central nervous system cancers: Recent trends in incidence and mortality.
J. Natl. Cancer Inst.
91
,
1382
-1390.

Levallois, P., Dumont, M., Touitou, Y., Gingras, S., Mâsse, B., Gauvin, D., Kröger, E., Bourdages, M., and Douville, P. (

2001
) Effects of electric and magnetic fields from high-power lines on female urinary excretion of 6–sulfatoxymelatonin concentration in women.
Am. J. Epidemiol.
154
,
601
-609.

Lewis, R. (

2001
) Use of rank-order analysis of ordinal exposure data: Application to vinyl chloride exposure.
Appl. Occup. Environ. Hyg.
16
,
188
-191.

Li, Y., Millikan, R.C., Carozza, S., Newman, B., Liu, E., Davis, R., Miike, R., and Wrensch, M. (

1998
) p53 mutations in malignant gliomas.
Cancer Epidemiol. Biomarkers Prev.
7
,
303
-308.

Linet, M.S., Ries, L.A., Smith, M.A., Tarone, R.E., and Devesa, S.S. (

1999
) Cancer surveillance series: Recent trends in childhood cancer incidence and mortality in the United States.
J. Natl. Cancer Inst.
91
,
1051
-1058.

Linos, A., Kardara, M., Kosmidis, H., Katriou, D., Hatzis, C., Kontzoglou, M., Koumandakis,E., and Tzartzatou-Stathopoulou, F. (

1998
) Reported influenza in pregnancy and childhood tumour.
Eur. J. Epidemiol.
14
,
471
-475.

Little, M.P., de Vathaire, F., Shamsaldin, A., Oberlin, O., Campbell, S., Grimaud, E., Chavaudra, J., Haylock, R.G., and Muirhead, C.R. (

1998
) Risks of brain tumour following treatment for cancer in childhood: Modification by genetic factors, radiotherapy and chemotherapy.
Int. J. Cancer.
78
,
269
-275.

Loning, L., Zimmermann, M., Reiter, A., Kaatsch, P., Henze, G., Riehm, H., and Schrappe, M. (

2000
) Secondary neoplasms subsequent to Berlin-Frankfurt-Munster therapy of acute lymphoblastic leukemia in childhood: Significantly lower risk without cranial radiotherapy.
Blood
95
,
2770
-2775.

Loomis, D.P., and Wolf, S.H. (

1996
) Mortality of workers at a nuclear materials production plant at Oak Ridge, Tennessee, 1947–1990.
Am. J. Ind. Med.
29
,
131
-141.

Lopez-Gonzalez, M.A., and Sotelo, J. (

2000
) Brain tumors in Mexico: Characteristics and prognosis of glioblastoma.
Surg. Neurol.
53
,
157
-162.

Lote, K., Stenwig, A.E., Skullerud, K., and Hirschberg, H. (

1998
) Prevalence and prognostic significance of epilepsy in patients with gliomas.
Eur. J. Cancer
34
,
98
-102.

Lubin, F., Farbstein, H., Chetrit, A., Farbstein, M., Freedman, L., Alfandary, E., and Modan, B. (

2000
) The role of nutritional habits during gestation and child life in pediatric brain tumor etiology.
Int. J. Cancer
86
,
139
-143.

Ma, F., Lee, D.J., Fleming, L.E., and Dosemeci, M. (

1998
) Race-specific cancer mortality in US firefighters: 1984–1993.
J. Occup. Environ. Med.
40
,
1134
-1138.

Malmer, B., Gronberg, H., Bergenheim, A.T., Lenner, P., and Henriksson, R. (

1999
) Familial aggregation of astrocytoma in northern Sweden: An epidemiological cohort study.
Int. J. Cancer
81
,
366
-370.

Malmer, B., Tavelin, B., Henriksson, R., and Gronberg, H. (

2000
) Primary brain tumours as second primary: A novel association between meningioma and colorectal cancer.
Int. J. Cancer
85
,
78
-81.

Malmer, B., Iselius, L., Holmberg, E., Collins, A., Henriksson, R., and Gronberg, H. (

2001
) Genetic epidemiology of glioma.
Br. J. Cancer
84
,
429
-434.

McCarthy, B.J., Davis, F.G., Freels, S., Surawicz, T.S., Damek, D.M., Grutsch, J., Menck, H.R., and Laws, E.R., Jr. (

1998
) Factors associated with survival in patients with meningioma.
J. Neurosurg.
88
,
831
-839.

McCredie, M., Little, J., Cotton, S., Mueller, B., Peris-Bonet, R., Choi, N.W., Cordier, S., Filippini, G., Holly, E.A., Modan, B., Arslan, A., and Preston-Martin, S. (

1999
) SEARCH international case-control study of childhood brain tumours: Role of index pregnancy and birth, and mother's reproductive history.
Paediatr. Perinat. Epidemiol.
13
,
325
-341.

McKinley, B.P., Michalek, A.M., Fenstermaker, R.A., and Plunkett, R.J. (

2000
) The impact of age and sex on the incidence of glial tumors in New York state from 1976 to 1995.
J. Neurosurg.
93
,
932
-939.

McLaughlin, J.K., and Lipworth, L. (

1999
) A critical review of the epidemiologic literature on health effects of occupational exposure to vinyl chloride.
J. Epidemiol. Biostat.
4
,
253
-275.

Meinert, R., and Michaelis, J. (

1996
) Meta-analyses of studies on the association between electromagnetic fields and childhood cancer.
Radiat. Environ. Biophys.
35
,
11
-18.

Minder, C.E., and Pfluger, D.H. (

2001
) Leukemia, brain tumors, and exposure to extremely low frequency electromagnetic fields in Swiss railway employees.
Am. J. Epidemiol.
153
,
825
-835.

Mizumatsu, S., Tamiya, T., Ono, Y., Abe, T., Matsumoto, K., Furuta, T., and Ohmoto, T. (

1999
) Expression of cell cycle regulator p27Kip1 is correlated with survival of patients with astrocytoma.
Clin. Cancer Res.
5
,
551
-557.

Mochizuki, S., Iwadate, Y., Namba, H., Yoshida, Y., Yamaura, A., Sakiyama, S., and Tagawa, M. (

1999
) Homozygous deletion of the p16/MTS-1/CDKN2 gene in malignant gliomas is infrequent among Japanese patients.
Int. J. Oncol.
15
,
983
-989.

Moen, B.E., and Ovrebo, S. (

1997
) Assessment of exposure to polycyclic aromatic hydrocarbons during firefighting by measurement of urinary 1–hydroxypyrene.
J. Occup. Environ. Med.
39
,
515
-519.

Morgan, R.W., Kelsh, M.A., Zhao, K., Exuzides, K.A., Heringer, S., and Negrete, W. (

2000
) Radiofrequency exposure and mortality from cancer of the brain and lymphatic/hematopoietic systems.
Epidemiology
11
,
118
-127.

Mundt, K.A., Dell, L.D., Austin, R.P., Luippold, R.S., Noess, R., and Bigelow, C. (

2000
) Historical cohort study of 10 109 men in the North American vinyl chloride industry, 1942–72: Update of cancer mortality to 31 December 1995.
Occup. Environ. Med.
57
,
774
-781.

Muscat, J.E., Malkin, M.G., Thompson, S., Shore, R.E., Stellman, S.D., McRee, D., Neugut, A.I., and Wynder, E.L. (

2000
) Handheld cellular telephone use and risk of brain cancer.
JAMA
284
,
3001
-3007.

Nakamura, M., Konishi, N., Tsunoda, S., Nakase, H., Tsuzuki, T., Aoki, H., Sakitani, H., Inui, T., and Sakaki, T. (

2000
) Analysis of prognostic and survival factors related to treatment of low-grade astrocytomas in adults.
Oncology
58
,
108
-116.

Narod, S.A., Stiller, C., and Lenoir, G.M. (

1991
) An estimate of the heritable fraction of childhood cancer.
Br. J. Cancer
63
,
993
-999.

Neglia, J.P., Meadows, A.T., Robison, L.L., Kim, T.H., Newton, W.A., Ruymann, F.B., Sather, H.N., and Hammond, G.D. (

1991
) Second neoplasms after acute lymphoblastic leukemia in childhood.
N. Engl. J. Med.
325
,
1330
-1336.

Nichols, K.E., Malkin, D., Garber, J.E., Fraumeni, J.F., Jr., and Li, F.P. (

2001
) Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers.
Cancer Epidemiol. Biomarkers Prev.
10
,
83
-87.

NIEHS (

1999
)
Health Effects from Exposure to Power-Line Frequency Electric and Magnetic Fields
. NIH publication no. 99–4493. National Institute of Environmental Health Scences, National Institutes of Health.

Norman, M.A., Holly, E.A., and Preston-Martin, S. (

1996
) Childhood brain tumors and exposure to tobacco smoke.
Cancer Epidemiol. Biomarkers Prev.
5
,
85
-91.

Olsen, J.H., Boice, J.D., Jr., Jensen, J.P., and Fraumeni, J.F., Jr. (

1989
) Cancer among epileptic patients exposed to anticonvulsant drugs.
J. Natl. Cancer Inst.
81
,
803
-808.

Pace, A., Bove, L., Innocenti, P., Pietrangeli, A., Carapella, C.M., Oppido, P., Raus, L., Occhipinti, E., and Jandolo, B. (

1998
) Epilepsy and gliomas: Incidence and treatment in 119 patients.
J. Exp. Clin. Cancer Res.
17
,
479
-482.

Peters, E.S., Kelsey, K.T., Wiencke, J.K., Park, S., Chen, P., Miike, R., and Wrensch, M.R. (

2001
) NAT2 and NQO1 polymorphisms are not associated with adult glioma.
Cancer Epidemiol. Biomarkers Prev.
10
,
151
-152.

Pobereskin, L.H., and Chadduck, J.B. (

2000
) Incidence of brain tumours in two English counties: A population based study.
J. Neurol. Neurosurg. Psychiatry
69
,
464
-471.

Pogoda, J.M., and Preston-Martin, S. (

1997
) Household pesticides and risk of pediatric brain tumors.
Environ. Health Perspect
.
105
,
1214
-1220.

Prados, M.D., Berger, M.S., and Wilson, C.B. (

1998
) Primary central nervous system tumors: Advances in knowledge and treatment.
CA Cancer J. Clin.
48
,
331
-360, 321.

Preston-Martin, S., and Mack, W. (

1996
) Neoplasms of the nervous system. In: Schottenfeld, D., and Fraumeni, J.F., Jr. (Eds.),
Cancer Epidemiology and Prevention. Second edition
. New York: Oxford University Press. pp.
1231
-1281.

Preston-Martin, S., Mack, W., and Henderson, B.E. (

1989
) Risk factors for gliomas and meningiomas in males in Los Angeles County.
Cancer Res.
49
,
6137
-6143.

Preston-Martin, S., Pogoda, J.M., Schlehofer, B., Blettner, M., Howe, G.R., Ryan, P., Menegoz, F., Giles, G.G., Rodvall, Y., Choi, N.W., Little, J., and Arslan, A. (

1998
) An international case-control study of adult glioma and meningioma: The role of head trauma.
Int. J. Epidemiol.
27
,
579
-586.

Raaschou-Nielsen, O., Hertel, O., Thomsen, B.L., and Olsen, J.H. (

2001
) Air pollution from traffic at the residence of children with cancer.
Am. J. Epidemiol.
153
,
433
-443.

Rachet, B., Partanen, T., Kauppinen, T., and Sasco, A.J. (

2000
) Cancer risk in laboratory workers: An emphasis on biological research.
Am. J. Ind. Med.
38
,
651
-665.

Rice, J.M., and Wilbourn, J.D. (

2000
) Tumors of the nervous system in carcinogenic hazard identification.
Toxicol. Pathol.
28
,
202
-214.

Robinson, C.F., and Walker, J.T. (

1999
) Cancer mortality among women employed in fast-growing U.S. occupations.
Am. J. Ind. Med.
36
,
186
-192.

Robinson, C.F., Petersen, M., and Palu, S. (

1999
) Mortality patterns among electrical workers employed in the U.S. construction industry, 1982–1987.
Am. J. Ind. Med.
36
,
630
-637.

Rodu, B., Delzell, E., Beall, C., and Sathiakumar, N. (

2001
) Mortality among employees at a petrochemical research facility.
Am. J. Ind. Med.
39
,
29
-41.

Ryan, P., Lee, M.W., North, B., and McMichael, A.J. (

1992
) Risk factors for tumors of the brain and meninges: Results from the Adelaide Adult Brain Tumor Study.
Int. J. Cancer
51
,
20
-27.

Ryan, P., Hurley, S.F., Johnson, A.M., Salzberg, M., Lee, M.W., North, J.B., McNeil, J.J., and McMichael, A.J. (

1993
) Tumours of the brain and presence of antibodies to Toxoplasma gondii.
Int. J. Epidemiol.
22
,
412
-419.

Salminen, E., Pukkala, E., and Teppo, L. (

1999
) Second cancers in patients with brain tumours—impact of treatment.
Eur. J. Cancer
35
,
102
-105.

Salvati, M., Artico, M., Caruso, R., Rocchi, G., Orlando, E.R., and Nucci, F. (

1991
) A report on radiation-induced gliomas.
Cancer
67
,
392
-397.

Sant, M., van der Sanden, G., and Capocaccia, R. (

1998
) Survival rates for primary malignant brain tumours in Europe. EUROCARE Working Group.
Eur. J. Cancer
34
,
2241
-2247.

Santana, V.S., Silva, M., and Loomis, D. (

1999
) Brain neoplasms among naval military men.
Int. J. Occup. Environ. Health
5
,
88
-94.

Sathiakumar, N., Delzell, E., Rodu, B., Beall, C., and Myers, S. (

2001
) Cancer incidence among employees at a petrochemical research facility.
J. Occup. Environ. Med.
43
,
166
-174.

Savitz, D.A., Cai, J., van Wijngaarden, E., Loomis, D., Mihlan, G., Dufort, V., Kleckner, R.C., Nylander-French, L., Kromhout, H., and Zhou, H. (

2000
) Case-cohort analysis of brain cancer and leukemia in electric utility workers using a refined magnetic field job-exposure matrix.
Am. J. Ind. Med.
38
,
417
-425.

Schlehofer, B., Blettner, M., Becker, N., Martinsohn, C., and Wahrendorf, J. (

1992
) Medical risk factors and the development of brain tumors.
Cancer
69
,
2541
-2547.

Schlehofer, B., Blettner, M., Preston-Martin, S., Niehoff, D., Wahrendorf, J., Arslan, A., Ahlbom, A., Choi, W.N., Giles, G.G., Howe, G.R., Little, J., Ménégoz, F., and Ryan, P. (

1999
) Role of medical history in brain tumour development: Results from the International Adult Brain Tumour Study.
Int. J. Cancer
82
,
155
-160.

Schreinemachers, D.M. (

2000
) Cancer mortality in four northern wheat-producing states.
Environ. Health Perspect
.
108
,
873
-881.

Schuman, L.M., Choi, N.W., and Gullen, W.H. (

1967
) Relationship of central nervous system neoplasms to Toxoplasma gondii infection.
Am. J. Public Health Nations Health
57
,
848
-856.

Scott, J.N., Rewcastle, N.B., Brasher, P.M., Fulton, D., MacKinnon, J.A., Hamilton, M., Cairncross, J.G., and Forsyth, P. (

1999
) Which glioblastoma multiforme patient will become a long-term survivor? A population-based study.
Ann. Neurol.
46
,
183
-188.

Shadan, F.F., and Koziol, J. (

2000
) Induced genome instability as a potential screening test for cancer susceptibility?
Med. Hypotheses
55
,
69
-72.

Shapiro, S., Mealey, J., Jr., and Sartorius, C. (

1989
) Radiation-induced intracranial malignant gliomas.
J. Neurosurg.
71
,
77
-82.

Shintani, T., Hayakawa, N., Hoshi, M., Sumida, M., Kurisu, K., Oki, S., Kodama, Y., Kajikawa, H., Inai, K., and Kamada, N. (

1999
) High incidence of meningioma among Hiroshima atomic bomb survivors.
J. Radiat. Res.
40
,
49
-57.

Shirts, S.B., Annegers, J.F., Hauser, W.A., and Kurland, L.T. (

1986
) Cancer incidence in a cohort of patients with seizure disorders.
J. Natl. Cancer Inst.
77
,
83
-87.

Simmons, M.L., Lamborn, K.R., Takahashi, M., Chen, P., Israel, M.A., Berger, M.S., Godfrey, T., Nigro, J., Prados, M., Chang, S., Barker, F.G., II, and Aldape, K. (

2001
) Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients.
Cancer Res.
61
,
1122
-1128.

Simonato, L., L'Abbé, K.A., Andersen, A., Belli, S., Comba, P., Engholm, G., Ferro, G., Hagmar, L., Langård, S., Lundberg, I., Piratsu, R., Thomas, P., Winkleman, R., and Saracci, R. (

1991
) A collaborative study of cancer incidence and mortality among vinyl chloride workers.
Scand. J. Work Environ. Health
17
,
159
-169.

Singh, G.K., and Siahpush, M. (

2001
) All-cause and cause-specific mortality of immigrants and native born in the United States.
Am. J. Public Health
91
,
392
-399.

Smith, M.A., Freidlin, B., Ries, L.A., and Simon, R. (

1998
) Trends in reported incidence of primary malignant brain tumors in children in the United States.
J. Natl. Cancer Inst.
90
,
1269
-1277.

Smith, M.A., Freidlin, B., Ries, L.A.G., and Simon, R. (

1999
) Response: Re: Trends in reported incidence of primary malignant brain tumors in children in the United States.
J. Natl. Cancer Inst.
91
,
973
-974.

Socie, G., Curtis, R.E., Deeg, H.J., Sobocinski, K.A., Filipovich, A.H., Travis, L.B., Sullivan, K.M., Rowlings, P.A., Kingma, D.W., Banks, P.M., Travis, W.D., Witherspoon, R.P., Sanders, J., Jaffe, E.S., and Horowitz, M.M. (

2000
) New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia.
J. Clin. Oncol
18
,
348
-357.

Sorahan, T., Hamilton, L., Gardiner, K., Hodgson, J.T., and Harrington, J.M. (

1999
) Maternal occupational exposure to electromagnetic fields before, during, and after pregnancy in relation to risks of childhood cancers: Findings from the Oxford Survey of Childhood Cancers, 1953–1981 deaths.
Am. J. Ind. Med.
35
,
348
-357.

Straif, K., Weiland, S.K., Bungers, M., Holthenrich, D., Taeger, D., Yi, S., and Keil, U. (

2000
) Exposure to high concentrations of nitrosamines and cancer mortality among a cohort of rubber workers.
Occup. Environ. Med.
57
,
180
-187.

Strauss, D., Cable, W., and Shavelle, R. (

1999
) Causes of excess mortality in cerebral palsy.
Dev. Med. Child Neurol.
41
,
580
-585.

Strickler, H.D., Rosenberg, P.S., Devesa, S.S., Hertel, J., Fraumeni, J.F., Jr., and Goedert, J.J. (

1998
) Contamination of poliovirus vaccines with simian virus 40 (1955–1963) and subsequent cancer rates.
JAMA
279
,
292
-295.

Strojnik, T., Kos, J., Zidanik,B., Golouh,R., and Lah, T. (

1999
) Cathepsin B immunohistochemical staining in tumor and endothelialcells is a new prognostic factor for survival in patients with brain tumors.
Clin. Cancer Res.
5
,
559
-567.

Surawicz, T.S., McCarthy, B.J., Kupelian, V., Jukich, P.J., Bruner, J.M., and Davis, F.G. (

1999
) Descriptive epidemiology of primary brain and CNS tumors: Results from the Central Brain Tumor Registry of the United States, 1990–1994. Neuro-oncol. [serial online], Doc. 98–13, January 19, 1999. URL neuro-oncology.mc.duke.edu.
Neuro-oncol.
1
,
14
-25.

Taiwo, B.O. (

2000
) AIDS-related primary CNS lymphoma: A brief review.
AIDS Read
.
10
,
486
-491.

Tedeschi-Blok, N., Schwartzbaum, J., Lee, M., Miike, R., and Wrensch, M. (

2001
) Dietary calcium consumption and astrocytic glioma: San Francisco Bay Area Adult Glioma Study, 1991–1995.
Nutr. Cancer
39
,
196
-203.

Teppo, L., Salminen, E., and Pukkala, E. (

2001
) Risk of a new primary cancer among patients with lung cancer of different histological types.
Eur. J. Cancer
37
,
613
-619.

Thomas, T.L., and Waxweiler, R.J. (

1986
) Brain tumors and occupational risk factors.
Scand. J. Work Environ. Health
12
,
1
-15.

Tornling, G., Gustavsson, P., and Hogstedt, C. (

1994
) Mortality and cancer incidence in Stockholm fire fighters.
Am. J. Ind. Med.
25
,
219
-228.

Trizna, Z., de Andrade, M., Kyritsis, A.P., Briggs, K., Levin, V.A., Bruner, J.M., Wei, Q., and Bondy, M.L. (

1998
) Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas.
Cancer Epidemiol. Biomarkers Prev.
7
,
553
-555.

Varner, A. (

1999
) Re: Trends in reported incidence of primary malignant brain tumors in children in the United States.
J. Natl. Cancer Inst.
91
,
973
-974.

Vena, J.E., and Fiedler, R.C. (

1987
) Mortality of a municipal-worker cohort. IV. Fire fighters.
Am. J. Ind. Med.
11
,
671
-684.

Weiland, S.K., Mundt, K.A., Keil, U., Kraemer, B., Birk, T., Person, M., Bucher, A.M., Straif, K., Schumann, J., and Chambless, L. (

1996
) Cancer mortality among workers in the German rubber industry: 1981–91.
Occup. Environ. Med.
53
,
289
-298.

Wennborg, H., Yuen, J., Axelsson, G., Ahlbom, A., Gustavsson, P., and Sasco, A.J. (

1999
) Mortality and cancer incidence in biomedical laboratory personnel in Sweden.
Am. J. Ind. Med.
35
,
382
-389.

White, S.J., McLean, A.E., and Howland, C. (

1979
) Anticonvulsant drugs and cancer: A cohort study in patients with severe epilepsy.
Lancet
2
,
458
-461.

Wiemels, J.L., Wiencke, J.K., Sison, J.D., Miike, R., McMillan, A., and Wrensch, M. (

2002
) History of allergies among adults with glioma and controls.
Int. J. Cancer
98
,
609
-615.

Wong, O., and Raabe, G.K. (

2000
) A critical review of cancer epidemiology in the petroleum industry, with a meta-analysis of a combined database of more than 350,000 workers.
Regul. Toxicol. Pharmacol.
32
,
78
-98.

Wong, O., Whorton, M.D., Foliart, D.E., and Ragland, D. (

1991
) An industry-wide epidemiologic study of vinyl chloride workers, 1942–1982.
Am. J. Ind. Med.
20
,
317
-334.

Wrensch, M., Bondy, M.L., Wiencke, J., and Yost, M. (

1993
) Environmental risk factors for primary malignant brain tumors: A review.
J. Neurooncol.
17
,
47
-64.

Wrensch, M., Lee, M., Miike, R., Newman, B., Barger, G., Davis, R., Wiencke, J., and Neuhaus, J. (

1997
) Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls.
Am. J. Epidemiol.
145
,
581
-593.

Wrensch, M., Yost, M., Miike, R., Lee, G., and Touchstone, J. (

1999
) Adult glioma in relation to residential power frequency electromagnetic field exposures in the San Francisco Bay area.
Epidemiology
10
,
523
-527.

Wrensch, M.R., Minn, Y., and Bondy, M.L. (

2000a
) Edpidemiology. In: Bernstein, M., and Berger, M.S. (Eds.),
Neuro-Oncology: The Essentials
. New York: Thieme Medical Publishers. pp.
2
-17.

Wrensch, M., Miike, R., Lee, M., and Neuhaus, J. (

2000b
) Are prior head injuries or diagnostic x-rays associated with glioma in adults? The effects of control selection bias.
Neuroepidemiology
19
,
234
-244.

Wrensch, M., Weinberg, A., Wiencke, J., Miike, R., Barger, G., and Kelsey, K. (

2001
) Prevalence of antibodies to four herpesviruses among adults with glioma and controls.
Am. J. Epidemiol.
154
,
161
-165.

Wu, W., Steenland, K., Brown, D., Wells, V., Jones, J., Schulte, P., and Halperin, W. (

1989
) Cohort and case-control analyses of workers exposed to vinyl chloride: An update.
J. Occup. Med.
31
,
518
-523.

Yeh, H., Matanoski, G.M., Wang, N., Sandler, D.P., and Comstock, G.W. (

2001
) Cancer incidence after childhood nasopharyngeal radium irradiation: A follow-up study in Washington County, Maryland.
Am. J. Epidemiol.
153
,
749
-756.

Zahm, S.H. (

1999
) Childhood leukemiaand pesticides.
Epidemiology
10
,
473
-475.

Zheng, T., Cantor, K.P., Zhang, Y., Keim, S., and Lynch, C.F. (

2001
) Occupational risk factors for brain cancer: A population-based case-control study in Iowa.
J. Occup. Environ. Med.
43
,
317
-324.

Author notes

Department of Epidemiology and Biostatistics (M.W., T.C.) andDepartment of Neurological Surgery and Brain Tumor Research Center (M.S.B.), University of California at San Francisco, San Francisco, CA 94143;Department of Neurology, Stanford University, Stanford, CA 94305 (Y.M.);Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, University of Texas, Houston, TX 77030 (M.B.)

© 2002 by the Society for Neuro-Oncology
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