Expression and significance of TWIST basic helix-loop-helix protein over-expression in gastric cancer
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Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient
2020, International Review of NeurobiologyCitation Excerpt :However, whether Twist is linked to angiogenesis or VM in glioma is still unknown. A number of studies have indicated that Twist is over expressed in breast cancer (Soini et al., 2011), prostate cancer (Kwok et al., 2005), and gastric cancer (Yan-Qi et al., 2007) etc. These findings suggest that Twist is associated with tumor genesis or tumor progression as a novel oncogene.
Linkage between EMT and stemness state through molecular association between TWIST1 and NY-ESO1 in esophageal squamous cell carcinoma
2019, BiochimieCitation Excerpt :Additionally, it prevents p53 function and cell apoptosis, stimulates expression of AKT2, and contributes in oncogenesis and angiogenesis [13,15]. Overexpression of TWIST1 was reported in a variety of cancers including prostate, bladder, breast, gastric and hepatocellular malignancies [16–21]. Upregulation of TWIST1 is correlated with decreased level of E-Cadherin expression, aggressiveness of the tumors, and patients’ poor survival rate [22].
A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway
2018, Biochemical PharmacologyCitation Excerpt :In addition, as a member of the bHLH transcription factor family, Twist1 is not only expressed in colonic macrophages. There is evidence that Th lymphocytes from the colon tissue of IBD patients and colonic epithelial cells from colorectal cancer patients also express Twist1 [28,43]. Our in vitro study demonstrated that TT-TFM showed no influence on the differentiation of Th1/Th17 lymphocytes and the activation of colonic epithelial cells.
Rab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT
2023, Cell Death and DiseaseDual role of E-cadherin in cancer cells
2022, Tissue BarriersThe many facets of miR-223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response
2021, Wiley Interdisciplinary Reviews: RNA
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these authors contributed equally to this work