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Nutritional epidemiology of cancer: accomplishments and prospects

Published online by Cambridge University Press:  27 March 2009

Pagona Lagiou
Affiliation:
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
Antonia Trichopoulou
Affiliation:
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
Dimitrios Trichopoulos*
Affiliation:
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
*
*Professor Dimitrios Trichopoulos, fax + 1 6 1 7 566 7805, email dtrichop@hsph.harvard.edu
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Abstract

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Nutritional epidemiology of cancer has gone through several stages. Initially, the long latency of cancer, the difficulties in undertaking long-term cohort investigations or ascertaining remote diet in case-control studies, and the absence of convenient intermediate biomarkers of disease, such as cholesterol in cardiovascular diseases, discouraged studies on diet and cancer. Subsequently, however, epidemiological successes in the chemical, viral and occupational aetiology of cancer, and the increasing insight into the sources of variation of diet and dietary information, prompted investigators to undertake both case-control and cohort studies. The results have been mixed. On the one hand, vegetables and fruits have been shown to be inversely associated with several forms of cancer. On the other hand, the information concerning specific macro- or micronutrients in relation to particular forms of cancer has been very limited and mostly inconclusive. There are several reasons for the complexity of investigations of the nutritional epidemiology of cancer and these reasons are briefly considered. An overview of our current understanding of the nutritional causes of cancer is also presented. It is noted that, notwithstanding the substantial gaps in our scientific knowledge, preventive nutritional approaches can be envisaged and they are likely to be moderately succeessful.

Type
Plenary Lecture
Copyright
Copyright © The Nutrition Society 2002

References

Clark, LC, Dalkin, B, Krongrad, A, Combs, GF Jr Turnbull, BW, Slate, EH, Witherington, R, Herlong, JH, Janosko, E, Carpenter, D, Borosso, C, Falk, S & Rounder, J, 1998 Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. British Journal of Urology 81, 730734.CrossRefGoogle ScholarPubMed
Colditz, G, Dejong, W, Hunter, D, Trichopoulos, D & Willett, W (editors) (1996) Harvard Report on Cancer Prevention Volume 1: Causes of Human Cancer. Cancer Causes and Control 7, Suppl. l, pp. 159.Google Scholar
Heinonen, OP, Albanes, D, Virtamo, J, Taylor, PR, Huttunen, JK, Hartman, AM, Haapakoski, J, Malila, N, Rautalahti, M, Ripatti, S, Maenpaa, H, Teerenhovi, L, Koss, L, Virolainen, M & Edwards, BK 1998 Prostate cancer and supplementation with alphatocopherol and beta-carotene: incidence and mortality in a controlled trial. Journal of the National Cancer Institute 90, 440446.CrossRefGoogle ScholarPubMed
International Agency for Research on Cancer (1987) Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, Suppl. 7. Lyon, France: IARC.Google Scholar
International Agency for Research on Cancer (1994) Hepatitis viruses. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 59, Lyon, France: IARC.Google Scholar
Marshall, J, Priore, R, Haughey, B, Rzepka, T & Graham, S (1980) Spouse-subject interviews and the reliability of diet studies. American Journal of Epidemiology 112, 675683.CrossRefGoogle ScholarPubMed
Rothman, KJ (1976) Causes American Journal of Epidemiology 104, 587592.CrossRefGoogle ScholarPubMed
Trichopoulos, D, Ouranos, G, Day, N, Tzonou, A, Manousos, O, Papadimitriou, Ch & Trichopoulou, A 1985 Diet and cancer of the stomach: a case-control study in Greece. International Journal of Cancer 36, 291297.CrossRefGoogle ScholarPubMed
Trichopoulou, A, Lagiou, P, Kuper, H & Trichopoulos, D (2000) Cancer and Mediterranean dietary traditions. Cancer Epidemiology Biomarkers and Prevention 9,869873.Google ScholarPubMed
Wacholder, S, Schatzkin, A, Freedman, LS, Kipnis, V, Hartman, A & Brown, CC 1994 Can energy adjustment separate the effects of energy from those of specific macronutrients? American Journal of Epidemiology 140, 848855.CrossRefGoogle ScholarPubMed
Wahrendorf, J (1987) An estimate of the proportion of colo-rectal and stomach cancers which might be prevented by certain changes in dietary habits. International Journal of Cancer 40, 625628.CrossRefGoogle ScholarPubMed
Willett, W (1998) Nutritional Epidemiology, 2nd ed. New York: Oxford University Press.CrossRefGoogle Scholar
Willett, W & Stampfer, MJ (1986) Total energy intake: implications for epidemiologic analyses. American Journal of Epidemiology 124, 1727.CrossRefGoogle ScholarPubMed
Willett, WC & Trichopoulos, D (1996) Nutrition and Nutrition and cancer: a summary of the evidence. Cancer Causes and Control 7, 178180.CrossRefGoogle ScholarPubMed
World Cancer Research Fund and American Institute for Cancer Prevention (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC: World Cancer Research Fund and American Institute for Cancer Prevention.Google Scholar