Release of cell fragments by invading melanoma cells
References (0)
Cited by (33)
Cripto-1 localizes to dynamic and shed filopodia associated with cellular migration in glioblastoma cells
2019, European Journal of Cell BiologyCitation Excerpt :Live-cell confocal imaging with lipophilic dye showed that these shed structures also retained the dye, an indication that the plasma membrane was still intact. A study published in 2004, observed and discussed a highly similar process with CD44 and Integrin β1-positive cell fragments shed from the trailing edge of melanoma cells embedded in a collagen matrix in vitro (Mayer et al., 2004). They reported that this process was Integrin β1-dependent and suggested that this represents a fundamental mechanism for cell detachment from adhesive substrates (Mayer et al., 2004).
Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs
2019, Developmental CellCitation Excerpt :While examining AC morphology, we detected spherical membrane structures that wild-type animals never displayed (n > 100). ACs in MMP− animals often (∼30%, n > 100) formed bleb-like structures that are attached to the cell body as well as detached tethered cell fragments (Figure S3E; Mayer et al., 2004; Wolf et al., 2003). These structures never formed at the AC’s invasive front, were usually not in contact with the BM, and were never observed penetrating BM (n = 50 animals observed) (Figure S3F).
Cell migration-The role of integrin glycosylation
2010, Biochimica et Biophysica Acta - General SubjectsSoluble adhesion molecules in human cancers: Sources and fates
2010, European Journal of Cell BiologyADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells
2009, Journal of Investigative Dermatology