GynecologyA population-based five-year follow-up study of cervical human papillomavirus infection☆,☆☆
Section snippets
Study group
Five hundred women who were residents of Stockholm, Sweden, were enrolled when attending the population-based invitational cervical screening program in 1991.17 This screening program invites all resident women aged 25 to 60 years to undergo examination, at first yearly and at >26 years of age at 3-year intervals. The attendance rate is about 65%. Fifty-six women with normal results of cervical cytologic examination had detection of cervical HPV DNA by polymerase chain reaction (PCR) with the
Reanalysis of 1991 cervical samples
Because only MY09 and MY11 primers had been used in 1991, the earlier samples were thawed and analyzed with GP5+ and GP6+ primers in 1997. Five of 46 samples from the cohort originally without HPV detection by MY09- and MY11-based PCR in 1991 had positive detection with the GP5+ and GP6+ primers. Conversely, 10 of 44 samples that had HPV detected by MY09- and MY11-based PCR in 1991 yielded negative results with the GP5+ and GP6+ primers (Table I).
For all 5 samples that had HPV detected with GP5+
Comment
Our estimate of a population-based 5-year clearance rate of 92% is well in line with results of previous follow-up studies, which have reported HPV clearance rates of >90% through 2 years of follow-up,7, 9, 10 and also well in line with estimates of the clearance rate derived from comparisons between HPV serologic results and HPV DNA detection.25 The tendency for the high-risk HPV type 16 to have a slower clearance rate has also been noted in several previous studies.7, 8, 10, 13 Thus our
Acknowledgements
We acknowledge Professor Britt-Marie Landgren and the staff at the Kvinnohälsan outpatient clinic for providing facilities and skilled assistance.
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Colposcopic and histopathologic evaluation of women with HPV persistence exiting an organized screening program
2020, American Journal of Obstetrics and GynecologyCitation Excerpt :A study in central Italy with a protocol in which women who were HPV positive/cytology negative were retested after 1 year reported a double increase in detection rates.21 By focusing on an age group of older women in whom lesion progression might be faster than in those at a younger age,22,23 we were able to draw conclusions for the specific management of women exiting the screening program. In our first assessment of the RHP, we showed that the HPV prevalence was 5.5% and the prevalence estimates for HPV16/18 were 1% and 0.3%, respectively.8
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Supported by the Swedish Cancer Society. Joakim Dillner, MD, PhD, is supported by the Swedish Medical Research Council and by the Nordic Academy for Advanced Studies.
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Reprint requests: Kristina Elfgren, MD, Department of Obstetrics and Gynecology, K57, Huddinge University Hospital, S-141 86 Huddinge, Sweden.