Planta Med 2005; 71(9): 867-870
DOI: 10.1055/s-2005-871292
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Flavonoids from Thelypteris torresiana

An-Shen Lin1 , Fang-Rong Chang1 , Chin-Chung Wu1 , Chih-Chuang Liaw1 , Yang-Chang Wu1
  • 1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
Further Information

Publication History

Received: November 11, 2004

Accepted: April 20, 2005

Publication Date:
19 August 2005 (online)

Abstract

During our search for anti-tumor agents from pteridophytes, three new flavonoids, protoapigenone (1), 5′,6′-dihydro-6′-methoxyprotoapigenone (2), and protoapigenin (3), along with four known compounds, protoapigenin 4′-O-β-D-glucoside (4), apigenin 4′-O-β-D-glucoside (5), kaempferol 3-O-α-L-rhamnopyranoside (6), kaempferol 3,7-di-O-α-L-rhamnopyranoside (7), were isolated from Thelypteris torresiana using bioactivity-guided fractionation methods. The structures of the new isolates were elucidated by 1D- and 2D-NMR spectral analysis. Among the 7 compounds, protoapigenone (1) exhibited significant anti-tumor activities toward Hep G2, Hep 3B, MCF-7, A549, and MDA-MB-231 with IC50 values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL, respectively.

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Prof. Dr. Yang-Chang Wu

Graduate Institute of Natural Products

Kaohsiung Medical University

100 Shih-Chuan 1st Road

San Ming District

Kaohsiung 807

Taiwan

R. O. C.

Phone: +886-7-312-1101 ext. 2197

Fax: +886-7-311-4773

Email: yachwu@kmu.edu.tw

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